Hi Juli,

I am the administrator of the K9 Diabetes forum - I checked and it looks like you are not yet a member (www.k9diabetes.com/forum) - and I have had only a quick skim of your thread.

But what I have had time to read and digest is scaring the pants off of me.

A couple of weeks ago, I might have been able to give you some fairly direct advice about an approach to take with Cooper with his insulin and the Cushing's question... now, in the face of two overdoses of Trilostane and no reliable idea of what his current natural levels of cortisol are...

The overall picture is a muddy mess and I don't think anyone can tell you what should be done with Cooper as far as Cushing's goes until things can be settled on a routine that keeps Cooper safe without Cushing's treatment and his natural cortisol production level can be determined.

If Cooper was my dog, I would, not give any more Trilostane, period.

Even in a diabetic dog, there is no rush to treat Cushing's disease, and Cooper's insulin dose was never raised to a level high enough to come close to determining whether he was "resistant" to insulin.

In fact, there were numerous signs that he responded well to insulin. Blood sugar in the 200s was quite good.

I'm gonna continue in a second post to address some other issues.

Natalie