Buddy, The Mighty Lizard Hunter - Suspected Pituitary Macro Tumor

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His illness came on very suddenly, although he's probably had Cushings for several years, Although I didn't know it. A few weeks ago he had a restless night and then woke up vomiting the next day. He also was so weak he was practically unable to stand. His back legs were wobbly and would not hold him up. After taking him to the vet and having numerous tests including blood work and x-rays, we were referred to the emergency hospital for a ultrasound. His liver was so large that they thought he had a tumor. It was difficult to see his other organs.

Hi and Welcome,

Yes, Trilostane/Vetoryl can cause an upset stomachFDA report of a study when first approving the drug"

[QUOTE]Adverse Reactions: Adverse reactions are reported here using the entire enrolled population of 75 dogs. Five dogs were withdrawn because of adverse reactions including lethargy, anorexia/inappetence, not drinking, vomiting, diarrhea, and muscle tremors.

The most common adverse reactions were vomiting (17.3 %), lethargy (17.3%), diarrhea/loose stools (14.7%), and anorexia (6.7%). Other adverse reactions were: nocturia, upset stomach, corneal ulcer, cough, persistent estrus, vaginal discharge and vulvar swelling in a spayed female, hypoadrenocorticism, electrolyte imbalance (elevated potassium with or without decreased sodium), collapse and seizure, shaking, constipation, scratching, weight gain, and weight loss.

Conclusions: Trilostane was effective in lowering post-ACTH stimulation cortisol levels and improving clinical signs in dogs with pituitary- and adrenal-dependent hyperadrenocorticism. The most comment adverse reactions were vomiting, lethargy, diarrhea, and anorexia.

But I am concerned. I know it is hard to write down everything and/or remember but could you round up copies of any blood work done and post abnormal findings? Cushings does not come on suddenly and should not he used in dogs with primary liver disease. Are the vets saying Cushings is the cause of the enlarged liver? Did the neurologist say the leg problems are soley due to muscle wasting from Cushings? It just feels like a part of the puzzle is missing.

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