Kathy thank you for sharing your story - My Penny is on trilo and had/has similar problems - when she started the trilo she also shivered thru her shoulder blades and sometimes from her shoulder blades down - also she has like a head tremor - she will be just laying looking around and then her eyelids start to blink very fast - her head jerks a few times and her mouth pulls backs alittle - it last only a few seconds - sometime a couple in a row but way to quick to video tape - she still has an appetite - likes her treats - her drinking is fine - just blew her coat but her legs are weak (she had 2 CCL repairs - and has a injured hock that couldnt be operated on a few years ago) so with the arthritis and the injury and the weaknes from the cushings she is having alot of problems with the walking and climbing - she is only on 10 mg of trilo and she is 82 lbs - but does awful on a high dose - she has stim test tomorrow so we will see where she is at - also lately she has been walking around alot at night like she has a cup of stong coffee - and she like to be downstairs alone alot - she does have a pituatary tumor but we do not know the size - so now I am assuming we need a CT -- I will talk to the vet in the AM - I do believe it is probably getting lager -she was said to of had cushings when she was 7 or 8 but did not need to go on meds till she was 11 - looking at her now I am really second guessing this - we may have missed something - I did have a golden with a brain tumor - he had grand mal seizures - had CT - did radiation but did not help him - thinking of him I do remember he did go off and like to be alone -- if you can comment on anything I mentioned I would appreciate it - thank you again