Have I finally found my friends? (Palmer has crossed over the Bridge)

[Harley PoMMom]

Hi Susan,

Trilostane always increases 17-hydroxyprogesterone (some cross-reactivity with pregnenolones in assays??), and frequently increases estradiol and androstenedione as well.

This is from the UTK treatment option sheet.
http://www.vet.utk.edu/diagnostic/endocrinology/pdf/Treatment%20Info,%20Atypical%20Cushing's,%20revise d,%20Oct.,%202009.pdf

The 5 intermediate/sex hormones: (Estradiol, Androstenedione, 17-
Hydroxyprogesterone, Progesterone and Aldosterone) all are made from the adrenal glands, now the estradiol is made from the adrenal gland and other places.

Since Trilostane increases some of these hormone levels, a pup's clinical signs can come back even when the cortisol is being controlled.

Hope this helps.

Love and hugs,
Lori