This is great news!! Don’t be surprised if more dosage tweaks are needed as time goes on, but the fact that Guido is responding so well to the split dose is a huge step forward. Hopefully from now on, only minor changes may be required in the future. And now that his cortisol is coming under control, there’s every reason to believe that he can continue onward with his normal lifespan. Please give him a huge hug for us, OK?