Hello Steve, and welcome to you and your boy! I’m surely sorry, though, for the problems you’re having. I know how much you want him to be feeling better. We’ll do our best to offer suggestions. But first, I have a few questions for you that’ll help guide us in our thoughts going forward.

First, can you tell us a bit more about your boy’s overall health history, his weight, and also the symptoms that led to the Cushing’s diagnosis? You’ve already mentioned the excessive urination — any other issues? Also, can you tell us about the testing that was done related to the diagnosis, including specific blood tests for Cushing’s as well as any other lab abnormalities? Any additional info you can share will be a help to us.

Unfortunately, even when Cushing’s is definitely the culprit, it can sometimes take time to arrive at the optimal dose of trilostane. Thus far, has your boy been getting his trilostane once a day? Some dogs end up responding better to a split dose given twice daily. For dogs who metabolize the drug quite quickly, the divided dose may extend the therapeutic effect more consistently throughout an entire 24-hour period. Also, every dose needs to be given along with a meal, regardless of whether it’s once or twice daily.

Anyway, I’ll go ahead and pause for now. Once again, we’re very glad you’ve found us and we look forward to learning more about your sweet boy.

Marianne