Hi, I've been looking for diagnosis of my dog, Pestka grom Poland, 12yo 5kg mix since Sept 2023. It all started with slightly increased drinking and hair regrowth arrest, no other signs, adrenals on ultrasound normal, ALP normal, ALT & GGTP increased (twice), blood count ok, T4 low, urine with weight low and some protein. Intern Vet inmediately tested her for cushing and both cortisol/creatinine (88) & LDDH were positive. She prescribed Seleginine at first, but my dog reacted cery badly to the drugi started drinking much more, was restless and started getting up at night. After withdrawing the drug, all the symptoms went back, too. The vet tried to put her on vetoryl, but she reacted with restlessness again. I consulted two endocrinology specialists, both aren't convinced it looks like typical cushing, so the vetoryl was withdrawn and we kept on searching. There were UTI coming now and then, she has been treated and the urine weight got a little higher (1,021), slight proteinuria stil there. The drinking is waving, but is not veeery excesive. She's been treated for hypothyroidism (ultrasound confirms it), but after 6 months the hair is not regrowning and the T4 isn't increasing either. Liver enzymes have decreased a little, after 9 months ALP is still ok (77 or so). She's has gastritis and reflux. Hunger is not an issue, always very good eater, but she doesn't go crazy. Sleeps at nights, wakes up very early, though. No high blood pressure. No movement problems. Adrenal glands still unchanged. Base cortisol in blood each time normal, endogenous ACTH normal, but cortisol/creatinine in urine high again.
Because of the poor hair regrowth my endocrino decided we do the ACTH test. I am cery scared it gives positive, I'm not convinced that the hair arrest is enough to start the vetoryl treatment yet☹️
What do you think? What's the usual time between the cushing signs and ALP show up? I'm reading the disease progresses slowly, but how slowly? Is it possible that after 9 months from the LDDH test the adrenals, ALP, etc. are still in the normal range, or maybe I should keep digging with the UT/renal/gastritis/thyroid issues? I'm stressed myself with all these tests and very afraid of cushing.