Your story certainly brings up another case with another of my dogs. Orlando's big sister was a rescued cavalier mix. As she aged, about 9, she had some irregular liver numbers, a definite low thyroid which we treated, but after my experiences with my first Cushing's dog, I also felt that she had that. Just as you describe, the LDDS kept coming back negative despite the fact that I felt that I observed other symptoms. So....it was never treated and about a month before I had to let her go, she was suddenly mostly blind. Your answer seems to give me another piece of the Mikki story.