A Veterinary formulation of Sam-e which is also available in many countries, including the UK, is called Zentonil.

Zentonil Brochure:
http://web.archive.org/web/200701272...s/Zentonil.pdf

http://www.vetoquinolusa.com/pages/global_03.html

http://animalmedicines.co.uk/product...productid=1095

Zentonil contains a pure, stabilised salt of S-Adenosylmethionine (SAM-e) in the tablet form.

Easy to use form of S-Adenosylmethionine (SAM-e) for cats or dogs. Unlike other forms of SAM-e supplementation, Zentonil tablets are enteric coated, to prevent SAM-e being digested by stomach acid. This ensures that the maximum amount is available for absorption from the duodenum.

Available in three strengths, for greater accuracy and ease of administration

- 30 x 100mg enteric-coated tablets

- 30 x 200mg enteric-coated tablets

- 30 x 400mg enteric-coated tablets

Importance of S-Adenosylmethione (SAM-e) for glutathione production:
S-Adenosylmethionine (or SAM-e) is a nucleotide –like molecule that is synthesised by all living cells. Derived from methionine and ATP, SAM-e initiates three major biochemical pathways: transmethylation, transsulphuration and aminopropylation. SAM-e is essential for the production of glutathione, a major liver antioxidant.

In a compromised liver:
Production of SAM-e synthetase, the enzyme that converts methionine to S-Adenosylmethionine (SAM-e), is decreased.

As a result, the supplemented methionine cannot be converted to SAM-e.

And the compromised liver is not able to produce the sufficient amount of glutathione - a vicious circle is created.

In a recent study, 51% of dogs and 82% of cats with liver problems were reported to be deficient in glutathione.*
By supplementing SAM-e, you are supporting the liver in producing glutathione and thus helping the liver to maintain its normal function.