Dr. David Bruyette is a nationally known veterinary endocrinologist and the medical director of VCA West Los Angeles Animal Hospital. Dr. Bruyette has recently joined us as a member here at k9cushings.com, and has graciously agreed to "field" general questions regarding trilostane treatment and monitoring. Of course, by answering our questions, he will not be assuming responsibility for overseeing the specific treatment of our dogs. Rather, his replies can help us to consult more knowledgeably with our own vets.

If you have questions about trilostane treatment and monitoring, please feel free to add a reply to this thread for Dr. Bruyette's consideration. Here is a quick dosing summary that he has already provided to us:

"In general about 80% of our patients do well on once a day dosing. We start at 3-5 mg/kg once a day in the AM and perform the ACTH stim test in 7-10 days. We switch to BID dosing when we don't have control of clinical signs and the 4 hours post ACTH stim is less than 9 ug/dl but the 24 hour ACTH stim is greater then 9 ug/dl. If we go BID we start at 2 mg/kg BID and recheck the stim again in 7-10 days."

Also, please take a look at this video summary of an interview with Dr. Bruyette that is included on our "Resources" forum:

"Trilostane dosing, monitoring, switching from mitotane to trilostane."

Many thanks in advance to Dr. Bruyette, and may the questions begin!