New here, searching for answers

[Nonie0206]

I have an 8 year old Lab mix, has always drank a lot of water, thought it was just her manner. This summer she started excessive peeing, losing her hair, panting, and more drinking than I have every seen her do. So in September had her tested for Cushings, it was positive. I realized that I had changed her to a new flea medicine in May called Simparica, which she took for 3 months. I became curious about this medicine and looked it up, found out the side effects from this medicine are similar to symptoms for cushing. Haven't started Sadie (my Lab) on Vetoryl at this time. I have stopped the flea medicine. And she seems to be getting better. Less drinking, peeing, and panting, and her hair may be starting to grow back. So I am not sure of the dx of Cushings. Vet didn't even want to test her for Cushings in the first place, said most likely not cushings. Can anyone comment you thoughts here please. I just don't trust the information I have gotten thus far, would love to hear from people who have dealt with this.

[labblab]

Hello and welcome to you and Sadie — as you can see, I’m a Lab lover, too :-))).

That’s so interesting that you’re seeing symptom improvement now that you’ve discontinued the Simparica. It’s not a med with which I’m familiar, so I’ve spent a little time Googling it. I see that the manufacturer’s published warnings about side effects focus mainly on neurological issues. I didn’t see anything in their literature about excessive thirst or urination. However, here’s an excerpt from the FDA’s 2020 approval announcement:

Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). While neurological side effects were not observed in these studies, sarolaner, one of the active ingredients in Simparica Trio, is in the isoxazoline drug class. FDA considers these drugs to be safe and effective, but the agency has issued a public alert that, in some cases, isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats.

https://www.fda.gov/animal-veterinar...ther-parasites

I’m guessing this may be what you’ve seen as well. Sadie’s hair loss wouldn’t be explained by this, but as you say, several other symptoms could possibly be related — or at least worsened by this med. In honesty, if Sadie were my own dog, I’d hold off on starting Vetoryl treatment, too, if her symptoms continue to normalize on their own. Even if Sadie genuinely has Cushing’s, there’d be little reason to start the Vetoryl since symptom resolution is the chief goal of treatment, anyway. Vetoryl would not “cure” the actual disease even if Sadie truly does have it. So I’d be inclined to wait and see what happens. If Cushing’s is actually present, you’ll likely see a rebound of symptoms over time. At that point, you can revisit both the diagnostics and your treatment decision.

I’m honestly very interested in knowing what happens with Sadie, so I really hope you’ll continue to update us, either way. And I appreciate learning that Simparica can possibly produce these Cushing’s-like symptoms. I’ll add it to my list of questions for other folks who come to us with concerns about excessive thirst/urination/panting.

Good luck to you two, and please do stay in touch!
Marianne

[Joan2517]

Hello and welcome from me, too. I would agree with Marianne and wait on starting Vetoryl, since she may not need it. Sadie's hair loss could still be an allergic reaction to the Simparica even if it is not listed with the other side effects. Every dog is different and reacts differently to things. We had a Saluki (Isis) who was diagnosed with canine lymphoma in the nineties, she was only six, and we always believed it was caused by the flea collar that we had put on her a few years before.

My Lena had a terrible reaction to Zodiac flea meds and the side effects lasted for about four days. She was a dog who never complained, but with this, she was hyper, whined and cried, and just couldn't get comfortable for days. It didn't bother any of my other dogs, just her. So you just never know...

[Nonie0206]

Thank You for a quick reply, I totally agree with you. Sadie had heart worms when I first got her from a rescue location. So she was on antibiotics for over a year for that issue. The only and biggest issue I have with her now is that her itching is continuous. Mostly on her head, and front feet occasionally other areas of her body. have been told that is probably due to the food, I have tried many different types of food, even went on home made for over 6 months, no change with any of them though.

[labblab]

So good to hear back from you! I’m sure sorry about the itching. We struggled with that, too, with our previous non-Cushing’s Lab girl. I tried so many different foods, too, but that never seemed to be the answer. I know there are some newer anti-allergy meds on the market now, but unfortunately I’m not knowledgeable about any of them. Just as a side note, historically steroids were frequently used as allergy treatments and probably still are. However, for any dog with Cushing’s or suspected of Cushing’s, steroids are a no-no unless absolutely necessary because they will “double” the problem of excessive steroid circulation in the body.

I surely hope you can find something to ease Sadie’s itchiness, though. And once again, please do keep us updated.

Marianne

[Nonie0206]

So good to hear back from you! I’m sure sorry about the itching. We struggled with that, too, with our previous non-Cushing’s Lab girl. I tried so many different foods, too, but that never seemed to be the answer. I know there are some newer anti-allergy meds on the market now, but unfortunately I’m not knowledgeable about any of them. Just as a side note, historically steroids were frequently used as allergy treatments and probably still are. However, for any dog with Cushing’s or suspected of Cushing’s, steroids are a no-no unless absolutely necessary because they will “double” the problem of excessive steroid circulation in the body.

I surely hope you can find something to ease Sadie’s itchiness, though. And once again, please do keep us updated.

Marianne

Thank you so much for replying, I find this site very hard to use, as I am not sure that this is the right place to post my reply to you. I may not post any more due to the difficulty of site use. Thank You so much Marianne!!

[Nonie0206]

Thank You Marianne!! Your opinion is very helpful, letting me know that I am feeling the same as someone else. That is VERY helpful. I was scared that I was feeling that no need for medications might make her symptoms worse or even worse than that. You seem to understand very clearly!!! Thank YOu!!