Thanks so much for your message and I am sorry too about yours that went through it. It's gut wrenching for sure because as you said we try and do what is best for them and try and help them with everything we know. I was the king of researching online and trying to get more educated with this disease. Even though she was never fully diagnosed we knew she had to have had it giving all the symptoms she had. The natural lignans and melatonin did help her alot I believe. I kick myself for not having her retested again last year and maybe putting her on actual meds. I also kick myself for not having any tests done to see if maybe her heart was having issues or enlarged..and also checking out her lungs and the breathing issue. So much guilt from that alone and then to keep thinking maybe the meds out her in that state just overwhelmes me. I know several people have said the same thing that most likely it was not the meds and just bad timing of everything. I look back and realize how many times she was breathing heavier and when I did bring her outside by the time we came in and I shut the door she would collapse and just sit there as if she was so tired and trying to catch her breath I believe. So weird that we have camera footage of her last week the day she passed and how she seemed normal overall.. sitting on the stairs landing and howling and barking..she looked fine..she would do that because she was lonely and most likely had separation anxiety..she pooped that morning and it looked fine...was really hungry and ate her topper fine and the treats I gave her..in fact she wanted more food lol..didn't eat her kibble I don't recall but that was normal for her alot of the days..or she would go back and eat it before my wife came home for lunch..she may have ate it by then..I can't remember. But my wife went home like normal and she was under her endstand and took her supplements (krill oil milk thistle and C) just fine..and then in time came out to kitchen to look for lunch..wife put kibble in her bowl and she was like ummm really? No thanks lol and sat down next to it ..our other footage of her was when she came home around 3:15 you could see Maia laying on the floor in the left hand corner..and she did look up and was alert and watched her come in etc..by then she pooped on 3 pads..all looked ok except some diarrhea drops at the end..so I think that's when that started..maybe side effects of the drug? By the time 4:30 hit..she was going downhill quick..drooling spaced out..couldn't really get up..and just went into a coma like...so odd. And i mean who wouldn't think the meds may have caused it?? That was my first reaction and what I said when I called the ER etc..was possible reaction..they even put that down on her summary. She didn't even get up when my wife was making hamburger around 3:45 ish.. was out like a light and snoring etc..again she had been battling mobility issues for a bit too..but still moved around of course and if food was involved she def would get motivated lol but nope not that time. So sad..sad how quickly.she went..I mean within 3 hours of it starting she died. I also say if it was clots..wouldn't it have killed her quicker?? Maybe it depends on severity of it too. I think what really gets to me is when the ER Dr said the amantadine MAY have possibly pushed her into that but was still doubtful..so the red flags go up with that..anyone else ever used amantadine and or meloxicam with their cush pup? Thanks to all..so hard and I know in time will get better.