Dear Joan,
I know there's probably nothing that anybody can say that will change your doubts and regrets about Lena's Cushing's treatment. But I decided to look back through your thread one more time, and having done so, I think that Sharlene was so wise in what she's just written -- that there's simply no way to know how things would have turned out had you travelled a different path. And truly, things might have been even worse. This is how you described Lena when you first joined us.
Goodness, little Lena had so many symptoms of Cushing's, and these were all problems that were robbing her of any decent quality of life
. Honestly, I don't see how
not treating her for Cushing's would have been a viable option for you, Joan. You listed above the outward signs, but we also know that she was suffering from internal Cushing's problems such as high blood pressure which carries so many risks for heart, kidneys, vision, etc. In the end, the vets believe it was a clot or cardiac emergency that prompted her respiratory failure. If so, these are symptoms of the disease and not of the treatment.
I truly do not believe the trilostane was the basis for Lena's problems. Even if we somehow hypothesize that she wasn't truly Cushinoid, she did suffer from abnormally elevated cortisol and that is not a healthy situation on a chronic basis. So taking medication to lower the cortisol would still help to lessen the risks of high blood pressure, clots, etc. Trilostane is even used to treat certain conditions that don't involve elevated cortisol at all.
So in my heart of hearts, I believe you did the right thing by treating her, Joan, and Cushing's or not, I do not believe the trilostane was the culprit here. Instead of the medication, I believe it was a clot, or her lungs, or her heart, and the end might have come even sooner had you not worked as you did to get the cortisol lowered.
Of course you know I'm not a vet, so this is only my personal opinion after following Lena's journey alongside you. But I just felt I had to write these words in the hope they may help you release some part of the guilt you are carrying. I don't believe you made a mistake, Joan. You are a wonderful, loving mom and you gave Lena the best chance that was within your power to grant her. I remain so deeply sorry that she just could not be healed.