I have been reading many of the threads the past few weeks (sometimes bawling my eyes out), trying to figure out what's been going on with Annie, my very charming (and willful ) Westie, who is 15 years & 9 months old.
I am so grateful to all of you for sharing your experiences, knowledge, and hearts. I was particularly intrigued by frijole's Annie, and my biggest hope is to be able to bring my Annie some relief to revive her spunk and see her wag her tail more. Excuse me for the novel-length 1st post, but I wanted to cram everything I could!
In a nutshell, Annie has a mass on her right adrenal gland, but apparently it is not secreting cortisol because her LDDS test does not indicate Cushing's. Based on more recent symptoms, I strongly suspect she has a pheochromocytoma, but today we saw a veterinary internal medicine specialist who thinks it's more likely that the tumor is not secreting anything and Annie's symptoms are more likely unrelated (a brain tumor or canine cognitive disorder)The doc suggested Anipryl, but backed off when I pointed out that IF it is a pheo, an MAOI in contraindicated (yes, I've been doing my homework! We both agree that Annie is not a good candidate for surgery due to her age, but I am going ahead with a CT scan of her abdomen and head on Thurs in the hopes that we can have a more definitive diagnosis and can manage symptoms and improve quality of life for whatever time Annie has left. Also will do a urine catecholomine test, which doc said if it's positive it could be non-pheo causes, but if it's negative, that would rule out a pheo.
Symptoms
She's been having many of the standard Cushing's symptoms, (started to notice on-and-off since last fall, but has been getting markedly worse since early July): recurrent skin infections, extreme hunger & thirst, potty accidents in the house, waking/pacing/anxious in the middle of the night, lethargic, bouts of panting, restlessness, can't seem to get comfortable, smacking her lips/licking, etc. I thought she was just getting old. She also doesn't wag her tail anymore (since last winter), but it still works -- she holds it out when we're walking outside and wags it when saying "hi" to strangers at the vet (my hubby says her wagger is broken)
More recently (July/Aug) - Annie also breathes hard sometimes when she's sleeping. She has head & whole body muscle twitches. Rubs face all over carpet, furniture, people & chews feet until bloody (so she's been wearing the cone of shame pretty much since April/eye surgery). Since July, she's had 2 bouts of no eating/vomiting bile, which is rare for her, although she's had a lifelong issue with "sensitive stomach" & allergies.
History
* In early April, Annie developed a corneal ulcer that was down to the last layer and about to perforate. Our vet had me put in eyedrops every 1-2 hours until we could consult with the only animal ophthalmologist in Hawaii, but thankfully, all was well (except my wallet) after a corneal pedicle graft. She was diagnosed with dry eye and I've been putting Tacrolimis ointment in her eyes since (we tried cyclosporine first, but she had a reaction that turned her into an evil-looking red-masked racoon from hell).
* In May, we suffered the heartbreaking loss of Annie's adopted sister, Ursa-bug (16 year old Shih-Tzu), who probably had Canine Cognitive Disorder.
* In June Annie had several teeth extracted and a benign growth removed from her skin (forehead). She healed very quickly from both surgeries, but the hair on the leg that was shaved in April has not really grown back (we call it her "chicken leg").
* June 28-July 9: We could not get rid of recurrent skin infections (medicated baths 2x/week & antibiotics), so doc put her on 10-day steroid dose and changed her food to Royal Canin Hydrolyzed Protein (HP)(over the course of 1 week) (previously ate Wellness CORE, reduced fat)
* July 15: Annie was sleeping next to me in the middle of the night and she suddenly yelped/screamed and started shaking all over for 2-3 minutes. Then she quieted down and seemed okay & went back to sleep. I thought maybe she had a bad dream, but after reading about pheos, this seemed like a sudden release of adrenaline?
* July 13-18: ravenously hungry, waking up at 2-3a crying, pacing, restless. Also urping yellow bile 2 or 3 times. I took her in to the vet on 7/18 and they do bloodwork. Diagnosis as after-effects of steroids.
* July 22-26: Stomach making noises, won't eat, & urping yellow bile. Doc gives her a shot for nausea on 7/26 and 4-day dose of Cerenia pills (anti nausea); change food (over 1 week) to Hills Venison & potato.
* Early August: 2a pacing, crying, won't settle. Feed her at 5a and she eats, but continues to act the same way. I'm concerned whether Annie is in pain or has Cushing's. Doc schedules LDDS test, ultrasound, x-rays. Ultrasound results below; x-ray does not reveal any apparent arthritis or spinal degeneration that would cause pain.
* Last night, she woke me up and I brought her downstairs where she emptied her water bowl and then threw up a few minutes later. It was 3:30a (6 hours since she'd last eaten), so I thought she was going to urp water/bile, but instead it was a thick, soupy brown "kibble stew" all over the carpet! Luckily, I did not wake up the household steamcleaning in the middle of the night, but there was no way to clean it otherwise. It seemed to make Annie feel much better, though, and she proceeded to try and "help" me with clean up duty!
Ultrasound - 8/11/15
Last week, an ultrasound revealed an adrenal gland mass (the gland was partially obscured, so they could not see it all, but the US report says it's "at least 1.9 x 3.0 cm). The left adrenal gland is normal. The liver is mind to moderately enlarged and mildly diffusely mottled in echogenicity. No focal hepatic parenchymal abnormalities are detected and no evidence of hepatic lymphadenomagaly is seen. Both kidneys contain cortical cysts, the largest of which is approx 1.9 cm in diameter. ... A scant volume of anechoic peritoneal fluid is present.
LDDS
Cortisol Sample 1, Baseline (0H): 2.6 (ref range 1.5-5.0)
Cortisol Sample 2, Dex (4 hr): 1.0 (ref range 0.0-1.4)
Cortisol Sample 3, Dex (8hr): <1.0 (ref range 0.0-1.4)
Bloodwork - not "normal" & compared to past 2 results
Alk Phosphatase: 161 (8/6/15), 217 (7/8/15), 90 (4/8/15), ref range 5-131
BUN: 34 (8/6), 30 (7/8), 34 (4/8) ref range 6-31
Potassium: 6.5 (8/6), 5.0 (7/8), 5.0 (4/8) ref range 3.6-5.5
Na/K Ratio: 22 (8/6), 30 (7/8), 31 (4/8) ref range 27-38
Platelet Count: 674 (8/6), 272 (7/8), 429 (4/8) ref range 170-400