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Diagnosis of Canine Hyperadrenocorticism Ian Ramsey BVSc PhD DSAM DipEVIM-CA MRCVS
SENIOR LECTURER IN SMALL ANIMAL MEDICINE
FACULTY OF VETERINARY MEDICINE, UNIVERSITY OF GLASGOW, BEARSDEN, GLASGOW. G61 1QH
From the proceedings of the Italian Association of Companion Animal Veterinarians at the Congresso Nazionale Multisala SCIVAC, 2005, Rimini, Italia
Diagnosis and Therapy of Hyperadrenocorticism in the Dog
Reto Neiger, Prof. Dr.med.vet., PhD, DACVIM, DECVIM -CA
Small Animal Clinic, Justus-Liebig University Giessen, Germany
Diagnosis of Hyperadrenocorticism in Dogs Mark E. Peterson, DVM
A presumptive diagnosis of hyperadrenocorticism in dogs can be made from clinical signs, physical examination, routine laboratory tests, and diagnostic imaging findings, but the diagnosis must be confirmed by use of pituitary-adrenal function tests. Screening tests designed to diagnose hyperadrenocorticism include the corticotropin (adrenocorticotropic hormone; ACTH) stimulation test, low-dose dexamethasone suppression test, and the urinary cortisol:creatinine ratio. None of these screening tests are perfect, and all are capable of giving false-negative and false-positive test results. Because of the limitation of these diagnostic tests, screening for hyperadrenocorticism must be reserved for dogs in which the disease is strongly suspected on the basis of historical and clinical findings. Once a diagnosis has been confirmed, the next step in the workup is to use one or more tests and procedures to distinguish pituitary-dependent from adrenal-dependent hyperadrenocorticism. Endocrine tests in this category include the high-dose dexamethasone suppression test and endogenous plasma ACTH measurements. Imaging techniques such as abdominal radiography, ultrasonography, computed tomography, and magnetic resonance imaging can also be extremely helpful in determining the cause.
Selecting the Most Appropriate Test for Hyperadrenocorticism Carmel T. Mooney, MVB, MPhil, PhD, DECVIM-CA, MRCVS
University Veterinary Hospital, School of Agriculture, Food Science & Veterinary Medicine, University College Dublin
Belfield, Dublin, Ireland
How to Interpret Tests for Canine Hyperadrenocorticism Carmel T. Mooney, MVB, Mphil, PhD, DECVIM-CA, MRCVS
University Veterinary Hospital, School of Agriculture, Food Science & Veterinary Medicine
Dublin, Ireland
ClinQuiz: Interpreting low-dose dexamethasone suppression test results
Test your knowledge of what these LDDS test results mean with this short quiz. The answers, with complete explanations, are provided.
By: David S. Bruyette, DVM, DACVIM
VETERINARY MEDICINE, Feb 1, 2009
Cushing's - Diagnosis
