Trilostane is the chemical name for a medication that effectively treats Canine Cushing's Disease. Worldwide, the only licensed veterinary version of trilostane is manufactured in the U.K. by the Dechra Group under the brand name of "Vetoryl." Vetoryl received FDA approval for sale in the U.S. beginning in 2009. Vetoryl is generally marketed in four dosage strengths: 10 mg., 30 mg., 60 mg., and 120 mg. capsules. In the U.S., 5 mg. capsules are also available.

All dosage strengths of brand name Vetoryl capsules are now sold in the U.S. by veterinarians and also via internet pharmacies. Additionally, several pharmacies in the U.S. are compounding and selling their own versions of trilostane for veterinary use. For members who obtain compounded trilostane, we encourage you to contact your pharmacy directly regarding the ongoing availability of specific dosage strengths.

Dechra's Recommendations Regarding Treatment and Monitoring


Dechra provides published information about Vetoryl as well as guidelines for its use. For U.S. pet owners, here are links to some especially helpful resources on Dechra's U.S. website, including direct contact information in the event that you or your vet have questions. Additionally, for all our owners worldwide, please take note that as of 2018, a new treatment monitoring protocol has been introduced by Dechra U.K./E.U. Please scroll down to find a posting re: this new, “Pre-pill” Vetoryl (trilostane) testing protocol.

Diagnosis, Treatment and Monitoring of Hyperadrenocorticism

Vetoryl Client Brochure

Vetoryl Technical Brochure

"Contact Us"

Dechra's U.S. Product Insert***

Dechra's newly revised initial dosing protocol (as of July, 2014)***


Here is a link to Dechra's international homepage. Once there, you can click on information that is specific to your own country or part of the world. In order to convert laboratory values from international charts and literature (nmol/l) into U.S. lab units (ug/dl), divide the values reported on the international charts by 27.59.

Dechra's International Homepage***


***PLEASE PROCEED TO THE NEXT POST IN THIS THREAD FOR DISCUSSION OF THE MOST RECENT INITIAL DOSING RECOMMENDATIONS FOR VETORYL (TRILOSTANE), BOTH IN THE U.K. and the U.S.