A decision regarding using a compounded version of trilostane is one that you must make in conjunction with your vet. Be aware that compounded versions of trilostane, while in widespread use, are not the equivalent of generics, and do not carry the same U.K./U.S. certifications as does Vetoryl. There are several pharmacies in the U.S. that are compounding and selling their own versions of trilostane for veterinary use. However, the FDA, various compounding pharmacies, and other interested parties are currently involved in ongoing discussion seeking to define the regulatory oversight associated with both human and veterinary compounding.

For more information regarding the use of compounded medications in the U.S., here is a recently revised brochure published by the American Veterinary Medical Association (AVMA). One section of particular interest is "Questions to Ask Your Pharmacist" in the event that a compounded drug is prescribed for your pet.

https://www.avma.org/resources-tools...th/compounding

https://www.avma.org/resources-tools...-veterinarians

https://www.avma.org/resources-tools...faq-pet-owners


Included in the "Veterinary Compounding" brochure is the following explanation as to the difference between compounded and generic drugs:

Generic drug products are very different from compounded preparations. Generic drug products are FDA-approved, which requires a demonstration of bioequivalence of safety and efficacy with the pioneer drug product. Generic animal drug products are identified by an Abbreviated New Animal Drug Application (ANADA) number on their label or in FDA drug references. In contrast to generic drugs, compounded preparations lack FDA approval.
Additionally, here is the first of a series of articles that discuss current legal and regulatory issues associated with veterinary compounding in the U.S. All subsequent articles can be accessed from Part 1.

"Confounding Compounding" Part 1
November 23, 2009
By: Edie Lau
For The VIN News Service:
http://news.vin.com/VINNews.aspx?articleId=14392