Reggie, an 8-ish pit mix who may have Cushing's and/or other issues

[ReggiesDad]

After a week off vetoryl, Reggie's cortisol rebounded to ~4.7 and his electrolytes are normal. So, looks like no lasting damage from potential over-treatment. He's also got borderline too much appetite, is urinating very copiously, and panting more than I'd expect although we are having a little warm spell. So we're resuming treatment, 50 mg twice a day for a month and then rechecking. I have enough 30 and 10 mg tablets on hand from earlier treaments to start out using them to add up to 50, but we are also going to see how he does on Chewy's 50mg compounded trilostane.

[labblab]

OK, sounds like a plan! I’m so relieved that Reggie is stable again at this point, and will surely be hoping that this turns out to be the optimal dose for him going forward. As always, we’ll be watching for your next update!

Marianne

[ReggiesDad]

So, externally Reggie was doing quite well on 50mg of Chewy-compounded trilostane twice a day. But while his latest bloodwork was fine for electrolytes, his cortisol was slightly lower than when our internist wanted to discontinue the 60mg. So she wants to take another week break and then try out 40mg twice a day. I guess after the last trilostane "break" this one is easier for me to accept as a good idea, Reggie's symptoms definitely came back during his last break but then cleared up just as quickly once he was back on the medications.

Meanwhile he's got hints of cataracts in both eyes, we're doing the best we can with his diabetes and blood sugar management but so many moving parts at the moment... There is no obvious effect on his vision and his opthamologist started him on Ketoroloac to hopefully prevent any inflammation. It doesn't seem like we need to be considering surgery "yet" but the thought of three weeks in a cone is kind of a bummer...

[labblab]

I definitely understand your dread of the cone. I personally had my own cataracts removed last summer, and even though there was no cone for me, I sure got tired of all the eyedrops, eyedrops, eyedrops I had to take!

I’m really glad to hear that, otherwise, Reggie has outwardly been doing well. Under these circumstances, I’m sorry that you’ve got to tweak the trilostane once again. But it really does sound as though that’s the safest route to go if his cortisol is heading back down.

Keep up the good work, Dad. Reggie is so lucky to have you, and we’re always so glad to get your reports!

Marianne