Our baby, Pearl, is a 10 year old french bulldog(maybe a little Boston terrier in her as well). She weighs 22lbs. She's never had any health issues but looking back now the Cushings symptoms have been present for the last 1.5 years, getting worse in the last 6 months. She has recently gotten a presumed diagnosis of Cushings. She had all the symptoms including the potbelly. Her bloodworm came back normal. The vet ruled out Diabetes and had her cortisol level checked in her urine which was very high. Pearl has extreme anxiety and goes into attack mode at the vet. We've had a vet tell us once she is the most dramatic dog they have ever seen. The only way they've been able to draw blood is to sedate her so they did not do the ACTH testing. The vet prescribed 30mg of Vetoryl. She's been taking the medication for 18 days as of yesterday. She responded so well at first. Less water chugging, less food crazed, less peeing, belly had started to seem less swollen, more active, more engaged with us, and overall a lot happier. We were thrilled and then yesterday afternoon after having meds and breakfast, started throwing up in the afternoon. I could tell she felt bad all day yesterday and she wasn't interested in her dinner and had some tremors through the night. Today is better but I did not give her meds this morning and called the vet. I guess I'm just wondering if its unusual for a dog to have a negative reaction after almost 3 weeks on the medication? It just seems so sudden and out of the blue. After reading the posts, I'm thinking maybe she needs to go to a lower dose. The vet said we could switch to 10mg in the morning and 10mg at night and told me to not stop the meds at all. Any advice is greatly appreciated. Thank you!