Diagnosis

[Frankiedoo]

Thank you for allowing me to join. Our almost 10 year old goldendoodle was diagnosed with PDH. It was a process getting here for sure. She was diagnosed in April 2020 with hypothyroidism. Her energy level improved and she lost the weight she had gained. However, her PUPD and appetite increased. I thought maybe she was over medicated, but she was not. Fast forward to August, I just knew something more was wrong. She had a mildly elevated ALT and steadily rising, but normal ALP. Her cholesterol was high, too. Her hair was thinning on her back end. She had an ultrasound and all looked good except for an ever so slightly enlarged liver. Her urinalysis came back with very dilute urine and she was losing protein. Her sdma and kidney numbers were normal. Her albumin and BUN were slightly low. We started on benazepril and a renal diet. I insisted on urine cortisol creatine test. It was sky high. She had the LDDS which confirmed Cushing’s. She is almost 60 pounds. She started on 20 mg of vetyrol 2X daily. We had a complication as she had a mast cell tumor on her leg. Thankfully it was low grade with clean margins. We started the vetyrol 2 weeks before surgery and had acth stim. Her levels were still high and her symptoms were no better. She has been on 30 mg 2X daily for the last 3 weeks. Her pupd is a little better but not normal. She’s still hungry!! I’m not sure if part of it is the low protein food. She had a urinalysis and acth stim yesterday. We expect to hear all results tomorrow. She has never had accidents, just drinks a lot with large volume of urine.

I appreciate any and all help/advice. Her last acth 3 weeks ago was 6.5 post and 5.1 pre.

Happy Holidays!
Amy

[labblab]

Hello Amy, and welcome to you and your boy! I’m afraid it’ll likely be tomorrow before I’m able to write a more thorough reply. But I wanted to at least have the chance to welcome you, and also to let you know that I’ve moved your thread here, to our main Questions & Discussion forum. People are more likely to see your thread here, and to have the chance to respond.

In the meantime, we’re really glad you’ve found us! And I look forward to having the chance to add more tomorrow.

Marianne

[Frankiedoo]

Thank you so much! My Frankie is a girl and she is excited, too.

Happy Holidays!

[labblab]

Oops, I’m so sorry about that!! You had written “she” and “her” so many times, but I still decided to make Frankie a boy, regardless. DUH! Anyway, so glad to have both you girls with us ;-)))))

[Frankiedoo]

LDDS
Pre - 5.0
Post 4 hours - 1.7
Post 8 hours - 3.3

*pre treatment

[Frankiedoo]

So apparently her levels increased on acth from xmas eve. Have you e er heard of this happening? Internal medicine doc wants to try 40 mg 2 x daily for 2 weeks. If no better, perform another ultrasound and additional work up.
Acth
Pre 6.6
Post 8.5

[labblab]

Just wanted you to know that I’ve not forgotten you, but today has turned out to be another crazy busy day for me. I promise I will make it back again tomorrow. Overall, though, it sounds as if your vet is making reasonable suggestions. But more to follow...

Marianne