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  1. #1
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    Default My sweet beagle Maia passed away last week

    Hello everyone..newbie here..about 5 years ago i noticed her hunger and thirst and then panting becoming prominent. I started researching online and found possible cushing's. So I made an appointment with vet and they did a ldds test on her and that came back inconclusive. I suggested UCCR test and that did come back abnormal. Put her on lignans and melatonin..did great.. Last May she developed a weird cough followed by gagging..talked it over with vet..said maybe copd but because she was acting ok activity wise etc So the coughing actually got a little less this past spring time..forgot to mention since last year she did have these weird breathing things..like her exhales was longer and more forced and prominent..during the night she did do these puffs of air with exhaling and she would change positions frequently..she was getting around worse and worse limping bad etc..so we went with adequan and it did help for a bit but then I felt the results weren't as good as I wanted. Nonetheless we kept her on it up until her death. A few weeks ago we put her in gabapentin for about two weeks..was 100mg twice a day..seemed ok..didn't really get lethargic from it but did get ataxia which is hind end weakness and she already had that. So we weaned her off per vet and discussed trying amantadine with meloxicam. ..I gave her her first dose last Sunday the 30th..she seemed ok..and by later on was actually getting around better..slight improvement. Next day the 31st gave her a second dose...was ok during the day..we have a camera set up in our family room and she was on the stairs landing..her favorite place..barking and howling..poor girl I think she had anxiety with us gone..but again seemed ok..by the time my mother got home at 3:15 ..she picked her head up as she was laying in other room our dining room and looked at her and looked at her going in the kitchen etc. All still seemed ok other than she was sleepy and a little blah feeling. My mother started making her burger for the week and she never reacted to it or got up like she would have or nothing..so she went and checked on her and she was out like a light snoring etc.. weird..then all of a sudden she heard a whimper and she had gotten up and moved into family room and pooped and peed then collapsed.. apparently had some drool coming out..poop was like cow slop..no blood..no vomit at all..I rushed home as I knew something was not right..when I got in she was just not with it.. looked at me and you could tell was uncomfortable..I picked her up..meanwhile she seemed like her limbs were rigid like and stiff..so now I'm thinking oh no..allergic reaction to meds..but then I say how..she had 2 doses..wouldn't it have been after first dose? And her dosage was low..she got 50mg of amantadine and a quarter of a tab of meloxicam which was a 7.5 mg one... Called her vet..they said stop the amantadine and it could be a reaction..although they were perplexed..they were closing soon and we're further away.
    So I called to her old vet who was open later etc but they couldn't get her in so we opted for ER clinic which was still about 50 minutes away..now keep in mind she seemed to be getting worse...now laying on side as I put her that way as she couldn't really keep herself upright..def labored breathing..not deep but more like shallow..and was basically going in a coma..she did recognize you were there if you went up to her and touched her face she flinched..but when I would rub her belly and or.neck area she would not react like she used to. So we took her to the clinic and they rushed her in saying she looked critical. On the way up she did lift her head several times and again she didn't seem to be struggling with breathing..wasn't panting..mouth not open gasping etc..we got the call that she was in respiratory distress and was in oxygen tent and they took imagining and her heart was larger than it should be..and based on age it wouldn't be wrong to say goodbye as they weren't confident she would come out of this or I could give 24 hours to see if the oxygen may stabilize her and they could run more tests and blood work etc..I said please do..and they were going to get an estimate how much it would be and call back. Well they called back very shortly and the ER doctor said she went into cardiac arrest and was gone. Just seemed to happen so quickly and I'm devastated. I did ask her about the meds maybe to blame and she said she didn't really think so and maybe slight chance of the amantadine triggering something but again doubtful. I got her xray and summary sent to my via email..it did say her heart walls looked really thick and not contracting well. Her regular vet said her heart didn't look that large to him and he has seen worse. And that it could have been a valve issue or her lungs.giving out which lead to cardiac arrest etc but it's speculation. Without an autopsy we don't know. But he too said he didn't think the meds played their part at all and he uses meloxicam all the time but didn't say much about the amantadine..which made me wonder .I did send her records to a chief of cardiology and he got back to me saying her heart was enlarged and it appears she may have been going through mitral valve disease but it's difficult based on one image..and with the ultrasound it suggests she may have had a PTE pulmonary thromboembolism as with cushing's they are prone to having clots etc and it appeared her right side of her heart wasn't pumping blood to the left side to lungs.he too said he doesn't think the meds did it..am I a wacko to keep wondering if maybe they did? I mean she had been sleeping a lot too and lethargic etc and would move around the house and collapse and lay there panting..so maybe it is more pulmonary like hypertension or heart related..the last couple months have been rough..with the limping..she didn't want to go outside much anymore so we had pee pads all over the one room so she could go on those.. and as all of you know..with cushing's they can become heat intolerant..and she def had that..she couldn't wait for bedtime and lay in front of the air conditioner..lol our summer here in upstate NY has been humid alot..so I was just hoping with the meds I was going to get her in a better place and with the cooler air coming we would walk more etc..ugh so torn over this. She did go on a walk two months ago and did great..would sit down from time to time but overall not that limpy and was good..but that was unfortunately her last one 😭☹️ although again I had high hopes of getting her back on track. She just kept losing muscle mass too..and the last couple months she was really losing her hair too in clumps but funny thing is she never had bald spots..maybe the melatonin helped with that. So I was curious what you guys thought and wondered if any of your dogs had an embolism or have or had pulmonary hypertension and also had the weird breathing like exhales that were prominent etc.. just trying to come to terms with this. I know I will never now a definitive answer as to what could have led up to her demise but maybe by talking to you guys I can learn about your experiences and what you are going or have gone through. God I miss her alot.. Thanks!

  2. #2
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    Default My sweet beagle Maia passed away last week

    I posted a longer one and can't find it.. hope it went through..I was curious if anyone's doggy had pulmonary hypertension or even died from or had pulmonary thromboembolism?? Mine died and imaging showed enlarged heart ..she had been battling some breathing issues..more so with her exhales..forced and prominent. I keep thinking the meds I recently put her on for her arthritis may have did something although I was told differently by a couple vets including a chief of cardiology. She took two doses in two days of amantadine and meloxicam and by that evening she was gone. Respiratory distress and then cardiac arrest. Hoping to get more insight with it all. Thanks

  3. #3
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    Default Re: My sweet beagle Maia passed away last week

    Hello and welcome to our forum. However, Iím so very sorry for the loss of your sweet girl. Iíll come back at another time to write more, but wanted to quickly let you know that your membership has been fully approved now, and Iíve combined both of your posts in this one thread. The reason why you couldnít see them earlier is because your membership was awaiting approval, and posts are not made visible to the public until that happens. But now youíre all set, and from this point onward, you can keep adding replies to this thread.

    Once again, Iím so sorry about Maia. I know the loss itself is so hard, but probably made even doubly painful when questions remain as to what happened. Weíll do our best to support you, and to share our thoughts. I wish I could write more now, myself, but as I say, Iíll have to postpone that until another time. But until then, Iím very glad that youíve found us.

    Marianne

  4. #4
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    Default Re: My sweet beagle Maia passed away last week

    Quote Originally Posted by labblab View Post
    Hello and welcome to our forum. However, Iím so very sorry for the loss of your sweet girl. Iíll come back at another time to write more, but wanted to quickly let you know that your membership has been fully approved now, and Iíve combined both of your posts in this one thread. The reason why you couldnít see them earlier is because your membership was awaiting approval, and posts are not made visible to the public until that happens. But now youíre all set, and from this point onward, you can keep adding replies to this thread.

    Once again, Iím so sorry about Maia. I know the loss itself is so hard, but probably made even doubly painful when questions remain as to what happened. Weíll do our best to support you, and to share our thoughts. I wish I could write more now, myself, but as I say, Iíll have to postpone that until another time. But until then, Iím very glad that youíve found us.

    Marianne
    Thanks so much for your reply... honestly when I first wrote this it was huge lol said it was too long to post..I said ughh and went through and deleted as much as I could as I pretty much have her whole life history from when we first adopted her. Lol but yes I miss her terribly and I am glad I found you guys as well. I'm very interested in learning about other experiences from others about their cush pups and if they ever had a terrible thing like this happen etc..ever had a pulmonary thromboembolism enlarged heart etc...was nice to hear back from that cardiologist from cornell university..he did put some things into perspective for me...I still can't get the meds out of my mind thinking maybe they did something to her ugh. I look forward to hearing from anyone that would like to chime in and I sure hope I can find peace from this soon. The wind is gone from my sails 😭

  5. #5
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    Default Re: My sweet beagle Maia passed away last week

    Hello and welcome from me, too. I'm so sorry for your loss. My Lena passed away in the Emergency Clinic four and a half years ago due to clots. She spent the first night in an oxygen tank, came home the next day, the same thing happened that night, back we went, and she went into distress after I had gone home. She had been having some funny breathing episodes for a week or so before, but the vet could find nothing wrong. She was doing a lot of sighing, which wasn't usual, but they kept telling me there was nothing wrong. Something was off, I knew it, but didn't know enough. I'm not sure if it would have changed the outcome anyway...I think of her every day and still miss her terribly.

    I don't think the meds had anything to do with it. We Cushing's parents live with guilt...did we do the right thing; should we have done more; did we do too much; why didn't we see the signs...I still feel guilty about Lee. I wasn't with her when they put her to sleep...she was the dog of my heart, my third child, and I wasn't with her when she died.

    I'm going through this Cushing's journey again with my big boy Gable. I watch him like a hawk for any signs of ANYTHING. He's younger than Lena was and is on a very low dose of Vetoryl. I dread the day I'm going to have to decide enough is enough...or he decides for me.
    Joan, mom to my Angel Lena, Doree, Gable, Cooper, Angel Phoenix and now Sibble.

  6. #6
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    Default Re: My sweet beagle Maia passed away last week

    Quote Originally Posted by Joan2517 View Post
    Hello and welcome from me, too. I'm so sorry for your loss. My Lena passed away in the Emergency Clinic four and a half years ago due to clots. She spent the first night in an oxygen tank, came home the next day, the same thing happened that night, back we went, and she went into distress after I had gone home. She had been having some funny breathing episodes for a week or so before, but the vet could find nothing wrong. She was doing a lot of sighing, which wasn't usual, but they kept telling me there was nothing wrong. Something was off, I knew it, but didn't know enough. I'm not sure if it would have changed the outcome anyway...I think of her every day and still miss her terribly.

    I don't think the meds had anything to do with it. We Cushing's parents live with guilt...did we do the right thing; should we have done more; did we do too much; why didn't we see the signs...I still feel guilty about Lee. I wasn't with her when they put her to sleep...she was the dog of my heart, my third child, and I wasn't with her when she died.

    I'm going through this Cushing's journey again with my big boy Gable. I watch him like a hawk for any signs of ANYTHING. He's younger than Lena was and is on a very low dose of Vetoryl. I dread the day I'm going to have to decide enough is enough...or he decides for me.

    Thanks so much for your message and I am sorry too about yours that went through it. It's gut wrenching for sure because as you said we try and do what is best for them and try and help them with everything we know. I was the king of researching online and trying to get more educated with this disease. Even though she was never fully diagnosed we knew she had to have had it giving all the symptoms she had. The natural lignans and melatonin did help her alot I believe. I kick myself for not having her retested again last year and maybe putting her on actual meds. I also kick myself for not having any tests done to see if maybe her heart was having issues or enlarged..and also checking out her lungs and the breathing issue. So much guilt from that alone and then to keep thinking maybe the meds out her in that state just overwhelmes me. I know several people have said the same thing that most likely it was not the meds and just bad timing of everything. I look back and realize how many times she was breathing heavier and when I did bring her outside by the time we came in and I shut the door she would collapse and just sit there as if she was so tired and trying to catch her breath I believe. So weird that we have camera footage of her last week the day she passed and how she seemed normal overall.. sitting on the stairs landing and howling and barking..she looked fine..she would do that because she was lonely and most likely had separation anxiety..she pooped that morning and it looked fine...was really hungry and ate her topper fine and the treats I gave her..in fact she wanted more food lol..didn't eat her kibble I don't recall but that was normal for her alot of the days..or she would go back and eat it before my wife came home for lunch..she may have ate it by then..I can't remember. But my wife went home like normal and she was under her endstand and took her supplements (krill oil milk thistle and C) just fine..and then in time came out to kitchen to look for lunch..wife put kibble in her bowl and she was like ummm really? No thanks lol and sat down next to it ..our other footage of her was when she came home around 3:15 you could see Maia laying on the floor in the left hand corner..and she did look up and was alert and watched her come in etc..by then she pooped on 3 pads..all looked ok except some diarrhea drops at the end..so I think that's when that started..maybe side effects of the drug? By the time 4:30 hit..she was going downhill quick..drooling spaced out..couldn't really get up..and just went into a coma like...so odd. And i mean who wouldn't think the meds may have caused it?? That was my first reaction and what I said when I called the ER etc..was possible reaction..they even put that down on her summary. She didn't even get up when my wife was making hamburger around 3:45 ish.. was out like a light and snoring etc..again she had been battling mobility issues for a bit too..but still moved around of course and if food was involved she def would get motivated lol but nope not that time. So sad..sad how quickly.she went..I mean within 3 hours of it starting she died. I also say if it was clots..wouldn't it have killed her quicker?? Maybe it depends on severity of it too. I think what really gets to me is when the ER Dr said the amantadine MAY have possibly pushed her into that but was still doubtful..so the red flags go up with that..anyone else ever used amantadine and or meloxicam with their cush pup? Thanks to all..so hard and I know in time will get better.

  7. #7
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    Default Re: My sweet beagle Maia passed away last week

    Hello. My name is CeeCee and Iím very new here. I just wanted to express my deepest sorrow for the loss of your Maia. Iím sure itís taken all of your strength to manage through your grief. Iíd like to wish for you that it get easier as time passes.

    Be safe and healthy

  8. #8
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    Default Re: My sweet beagle Maia passed away last week

    Thanks so much for the kind words!! It's def a struggle..I have bad days and I have better days..never any good days..14 years with her and for the last few months or more was a routine..and now it's all gone..bed is empty..no more smells or sounds of her..and I continually bash myself of the what ifs..but in the end I know she is at peace now..no more dealing with this disease and hobbling around the house..no more with the breathing etc. I'm just selfish because I want her back badly. It just seems like it came to an end fairly fast. And the mystery of what exactly happened is what drives me nuts. Thanks again for the condolences. Much appreciated. I wish you the best with yours( assuming you have a cush pup of course) just cherish every moment with them because time does fly and sadly they don't live as long as us ☹️

  9. #9
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    Default Re: My sweet beagle Maia passed away last week

    Hey everyone.. haven't checked in in a long time. I'm getting better but still miss Maia terribly. It's funny because I had a dream about her last night. In the dream I knew was gone but yet I saw her ghost walking into living room to her favorite spot under the end stand and I said her name and she came running over to me and was so excited to see me and I told her how much I missed and loved her etc..so weird as it felt so real. I get grief stricken at the weirdest times and other times I'm ok and don't think about her as much. But it's that one time or thing that triggers it. Ugh 😩 hope all of you are well!!! I did hear back from another cardiologist I reached out to a while ago. She said looking at the image there was no pattern of heart failure. Her heart did look a little enlarged like others said but she had in her opinion non cardiogenic pulmonary edema. Which can be triggered by a lot of things. So of course could be the meds or still maybe a PTE. Unfortunately I will never know. And that's what I struggle with the most. Ahh again hope you're well!

  10. #10
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    Default Re: My sweet beagle Maia passed away last week

    Hi Steve! It’s really good to hear back from you again. For sure, grieving is an unpredictable journey. Some days it seems like you get to take two steps forward and only get stuck with one step back. Other days there can be a whole lot of back-stepping. Your dream sounds pretty amazing, though. I know it probably felt sad when you had to wake up, but so sweet that you got to tell Maia once again how much you love her (and always will).

    All the information you’ve been gathering may never be able to give you a definite answer one way or another. There may always be a few pieces missing from the puzzle. But hopefully with all you’ve been able to learn and talk over, a day may come when you feel as though enough of the puzzle has been completed that at least you’ll be able to find some peace in knowing that you put together the most complete picture that was possible for anybody to fill in.

    I know that with the fall and winter holidays coming up, you may find yourself especially missing Maia even more than usual. So we’ll be right here, any time you feel like stopping by once again. Take good care of yourself in the meantime!

    Marianne

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