Hi all - our 4 year old pup Winnie was recently diagnosed with Cushings. It started with some urine leaking while she slept which was initially thought to be general incontinence. However, she began to eat and drink excessively and gained some weight. After a urinalysis and some bloodwork our vet diagnosed her with Cushings. This all seems to have happened almost overnight. Winnie was always a very active (and somewhat anxious) dog, and she's now just very lethargic and generally just seems like she is depressed. She has been on 30mg Vetoryl (twice a day) for a few months now. It has helped curb the thirst and overeating, and therefore helped with the leaking, but Winnie still just isn't herself. She doesn't get excited to do anything anymore.

She only seems to have about half of the symptoms that I've read about - she doesn't have hair loss, skin infections, or pot belly... plus she seems to be extremely young for a Cushings dog. Her blood work seemed to have been "borderline" but her urine cortisol creatinine numbers were very high from what i understand. I got the idea that perhaps her baseline blood numbers were a little high because she's such an anxious dog and we decided to go to another vet for a 2nd opinion. After our first visit with the new vet he strongly seems to think that Winnie doesn't have Cushings after all, based on her physical appearance and the "borderline" blood numbers coupled with what he said were normal liver enzyme levels, I believe. He instructed us to stop the Vetoryl and get back on a different medicine for incontinence. However, she immediately regressed and is now back to drinking/eating like crazy and having lots of leaking issues - i dont think these are signs of estrogen incontinence. She's leaky because shes drinking so much. She is still very lethargic and not playful (she WANTS to play but just seems that she can't). She also doesn't seem to want to sit down - i'm unsure if her legs are in pain or something else is hurting her. She also sometimes breathes heavily when resting.

I'm just very frustrated with this whole thing. I know it can take a while to get a good balance with the medicine but the fact that I don't even have a doctors' consensus as to the diagnosis is making things much more confusing. I don't know what to even try next. Has anyone had any similar experience? She's only 4 years old - i can't imagine that we can't get this figured out...

FWIW - we haven't had an ultrasound but i'm thinking of just demanding that we get one done. If it's not Cushings then it has to be something else affecting the adrenal gland I imagine...

thank you!