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Thread: Newbie needs help

  1. #11
    Join Date
    Mar 2009
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    rural central ARK
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    14,226

    Default Re: Bravecto & Milbemax

    If you are absolutely positively sure the food will be eaten, before is ok. It is better to wait and give after the meal or at least half way thru the meal to make sure the tummy has fats onboard so the drug will be absorbed.
    "May you know that absence is full of tender presence and that nothing is ever lost or forgotten." John O'Donahue, "Eternal Echoes"

    Death is not a changing of worlds as most imagine, as much as the walls of this world infinitely expanding.

  2. #12
    Join Date
    Sep 2019
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    10

    Default Trilostone

    I may be having a senior moment here but I am confused with compounded trilostone (I am in the UK). Teddy is currently on 10mg vetroyl once a day. We saw the specialist vet a couple of weeks ago who wants to keep him on 10mg but go to 5mg twice a day. We cant get 5ml vetoryl in the UK so I have picked up compounded liquid from my regular vets this morning. I've got home and it says 10ml on the bottle. Is this right? I don't know why but I expected it to be 5ml. Am I just being thick? Also do I have to leave 12hrs between each dosage? I usually feed at 9am, 12 and 4pm (3 small meals as he has been on a diet). If I understand correctly I would have to give last feed at 9pm? That would be terrible because his appetite has never diminished and he's hungry ALL the time. I've finally got his weight down by 1kg and do not want him putting on any more weight through over feeding. Help!!!

  3. #13
    Join Date
    Mar 2009
    Location
    rural central ARK
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    14,226

    Default Re: Trilostone

    Liquid med doses can easily be confusing so don't feel bad. The bottle should say something like 50mg/ml or 10mg/ml or 20mg/ml. Then it will tell you how many ml to give. So if you are using one that says 20mg/ml and you are told to give 0.5ml you would be giving 10mg with each dose (20 x .5 = 10). So the mg per ml (mg/ml) is what you need to know.

    As for the timing, it is best to give the med as close to 12 hours apart as possible. So you might start breakfast at least an hour earlier and the feed supper at least an hour later so the med is closer to 12 hours apart. I used Lysodren to treat so someone who used Vetoryl may think differently and I am sure you will hear from one of those users soon....I just know that Vetoryl needs to be given as close to 12 hours apart as possible when dosing twice a day.

    How is Teddy doing? Do you know what the results were of his most recent ACTHs? Especially the latest one? Are his signs improving?

    Good to hear from you again! Don't panic over the liquid...as soon as you get used to the dosing I think you will find this is a great way to treat because the liquid makes it very very easy to adjust doses as needed. And often makes it easier to give the medication period as those capsules can often be an issue with the pup.

    Hugs,
    Leslie
    "May you know that absence is full of tender presence and that nothing is ever lost or forgotten." John O'Donahue, "Eternal Echoes"

    Death is not a changing of worlds as most imagine, as much as the walls of this world infinitely expanding.

  4. #14
    Join Date
    Apr 2009
    Location
    Georgia
    Posts
    14,349

    Default Re: Trilostone

    Welcome back to you and Teddy! Youíll see that Iíve merged your new post into your original thread about Teddy. This way, weíll be able to keep track of his entire treatment history ;-).

    Switching to liquid trilostane can definitely be a bit confusing to begin with. This is because the dosing instructions have to be given in terms of a *liquid* measurement (like ml.) as opposed to a measurement of weight or *mass* (like mg.). So in terms of liquid dosing, the key issue is how many mg. of medication have been dissolved in how many ml. of fluid. And then, in turn, how many ml. of fluid do you give to make up a dose. The label on the bottle should tell you that, and Iím assuming the concentration of the liquid on Teddyís bottle means that 10 ml. of fluid will contain 5 mg. of trilostane. But if youíll tell us exactly what the label on the bottle says, we can help make sure thatís true.

    As far as the timing of the dose, I donít think it has to be exactly 12 hours apart. But it would probably be better if you could stretch it out further then just 7 hours apart. Maybe break his overall total into four meals rather than three, and give the last one at 7:00? Or move breakfast up to 8:00 and shift dinner to 6:00? I think it would be good to try to get at least ten hours in between. But the bottom line is probably just to check back with the specialist. Who knows, he may not care that much about the actual timing just as long as there is some degree of separation with the doses.

    Overall, how is Teddy doing these days? Itís great to hear back from you, and weíll look forward to more updates if youíre able to write again.

    Marianne

  5. #15
    Join Date
    Sep 2019
    Posts
    10

    Default Re: Trilostone

    Hi Leslie. Thanks for your reply on both sites: Teddy has been back and forth to a specialist vet for CT and ultrasound scans as his drinking, panting and still ravenous appetite were back and his liver enzymes hit 3000. Adrenals and liver enlarged and although scans didn't show it the vet has said his cushings is pituitary. Nothing else untoward. He didn't want to increase the dose of 10mg - he weighs 9.2kg but wants to try splitting in to 2 doses a day. He'll have another ACTH in 10 days after starting new regime. So sort of back to square one but I'm hoping with the compounded trilostone we can get a better handle on dosage. He was overdosed on vetoryl by another vet when we first started out on this journey and he nearly went in to Addisons so hence I want to double check before administering anything now. Thanks for your help x

  6. #16
    Join Date
    Sep 2019
    Posts
    10

    Default Re: Trilostone

    hi Marianne
    Im not sure how to attach a photo but all it says on the bottle is 10mg/ml in 50ml bottle. The label from my vet says to give 0.5mls twice daily.

  7. #17
    Join Date
    Apr 2009
    Location
    Georgia
    Posts
    14,349

    Default Re: Trilostone

    Quote Originally Posted by jem69 View Post
    hi Marianne
    Im not sure how to attach a photo but all it says on the bottle is 10mg/ml in 50ml bottle. The label from my vet says to give 0.5mls twice daily.
    That’s great — that’s what we needed to know. This means that every ml. of liquid contains 10 mg. of trilostane. So in order to give Teddy a 5 mg. dose of trilostane, you’ll be giving him 1/2 a ml. of liquid.

    I’m assuming they gave you a syringe or a measuring spoon of some type?

  8. #18
    Join Date
    Sep 2019
    Posts
    10

    Default Re: Trilostone

    Thank you so much for clarifying Marianne. I can now start him tomorrow instead of waiting to talk to the vet on Monday. Yes thankfully I got 2 syringes.

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