Re: Cushings, coritzol, calcinosis cutis, and inflamation
Hi and welcome to and Reggie!
Unfortunately CC will not get better without treatment - it gets progressively worse. Since you say her skin has improved off the Trilo I am wondering about the original diagnosis. CC is calcium that gets deposited under the skin and it works its way out of the body THRU the skin causing terrible sores that can cover the whole body if left untreated. So this improvement off treatment is a bit confusing to me if, IF, the CC diagnosis is correct. If possible I would have a derm vet take a look at her and find out for sure what is going on with her skin. There are several skin conditions that dogs can get other than CC and they have nothing to do with Cushing's.
Some dogs can't handle Trilostane at any dose tho that is uncommon. Typically the reactions you saw are due to the dose being too high. But at 30lbs the 15 a day is below the recommended starting dose of 1mg/lb so it may be that Reggie is simply one of those pups who can't take Trilo. Since you posted in kg VS lbs I am assuming you are in Europe somewhere? If so, you may not have any other option. In the US we have Lysodren that is also used to treat Cushing's and those pups that can't handle the Trilo can be switched to Lyso. There are also dogs who can't handle Lyso and need to switch to Trilo - so we are fortunate here that we do have options.
What signs did you or her vet see that prompted the Cushing's testing in the first place? Cushing's is one of, if not THE, most difficult canine condition to correctly diagnose because so many other diseases share the same signs AND any other condition can cause false positives on the tests for Cushing's. The LDDS is notorious for that if a non-adrenal disease is present. The ACTH measures how much cortisol the adrenals are holding in reserve and they will hold a lot in reserve if something like a tumor is present. Some dogs get so stressed simply walking in the vet's door that they will get positive results on the ACTH when they do not have Cushing's at all. So if you would let know us a bit of her medical background, especially anything going on around the time she was tested for Cushing's, that would be great. Has she had an abdominal ultrasound?
I'm glad you found us and look forward to learning more about the both of you as time passes.
Hugs,
Leslie
"May you know that absence is full of tender presence and that nothing is ever lost or forgotten." John O'Donahue, "Eternal Echoes"
Death is not a changing of worlds as most imagine, as much as the walls of this world infinitely expanding.