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Thread: Lysodren at $14.00 a tablet, 3 times a week - precious girl has passed

  1. #1
    Join Date
    Apr 2019
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    Default Lysodren at $14.00 a tablet, 3 times a week - precious girl has passed

    Our ten year young Lab has Cushings. We have her on Lysodren on a MWF schedule for her meds.

    Basically three tablets a week. We started her last year and were paying $5.00 a tablet at Sam's Club which no longer carries it. Since Bristol Meyers Squibb "divested" themselves of the Lysodren drug to another pharma company we can only buy it from Direct Success and are now paying $14.00 a tablet. Does anyone have a recommendation or have you been able to get it or a generic cheaper from somewhere else? At $43.00 a week for her meds, it is starting to add up quick. Thanks for anyone's help.

  2. #2
    Join Date
    Apr 2009
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    Georgia
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    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Hello and welcome! Unfortunately, it seems as though Direct Success is currently the only U.S. source for brand name Lysodren. One of our staffers, Leslie, wrote about this last fall when the price per pill was $7; sadly, it sounds as though that price has now doubled. Iíll give you the link to Leslieís post, however, because in it she discusses a less expensive alternative that may be an option for you to discuss with your vet ó compounded mitotane (the active chemical ingredient in Lysodren). Hereís the link:

    https://www.k9cushings.com/forum/sho...odren-shortage

    Good luck!
    Marianne

  3. #3
    Join Date
    Feb 2019
    Location
    Spring Valley, Il
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    173

    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Sorry Everyone, I just had to jump in on this one. I buy my Lysodren from Chewy.com and the first time I ordered, it was 30 tablets for a little over 8$ per tablet. Their price is now up to 12.18 per tablet. This is for a 500mg tab.

    They transferred my call to the pharmacy and I asked where they obtained their Lysodren and was told the Bristol Meyers Squibb plant in Italy. That didnít bother me as much as this sudden price increase within a month.

    I do watch the market (CNBC) and know that Bristol Meyers was either recently bought out or they bought out another company. The pharmacist at chewy confirmed this information for me but didnít have any details.

    To you with your lab, Iím sincerely sorry you are having to deal with this disease in your pup. I have a 10 year old miniature schnauzer who is currently on 250mg of Lysodren twice a week and is doing ok so far. She had to have emergency gallbladder removal surgery a week ago and she is also diabetic. I was very worried about giving her the Lysodren post surgery but she has been a super trooper with no ill effects in spite of all the extra meds she is on right now.

    Leslie on this forum is our Lysodren expert and is a wealth of information. When I read the post, I just had to do my own research for myself as well.

    If buying your drugs from a US based company is important for you, I canít be of much help right now.

    The most important thing for you to remember is that everyone here on this forum is here for you and your precious pupóthrough the good times and not so good. Iím just newbie here myself, but these wonderful people scooped me up in their arms and have not let go. Be well and blessings to you and your pup. Karen

  4. #4
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    Apr 2009
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    Georgia
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    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Karen, it’s great that you jumped in. Your reply got me to do a little more digging myself, and there are some unanswered questions here. First, it appears that there remain multiple sources of less expensive Lysodren. Online, I found Petco, VetRx Direct, and Allivet all listing prices per tablet of $8 or less. Also, the GoodRx site listed multiple instore pharmacies in my area with pricing that equals around $6 per tablet when using GoodRx’s coupon (GoodRx.com is a great resource for discounted human meds, as well).

    Leslie had written last fall that we could expect to see Bristol Myers Squibb product available for a while, until existing supplies ran out. So perhaps these are still pre-existing stockpiles. However, BMS’s U.S. website, current to today, still lists Lysodren as being under their manufacture:

    https://www.bms.com/patient-and-care...medicines.html

    So now I’m totally puzzled, and wonder whether the planned divestiture of Lysodren to HRA Pharma fell through, and BMS has perhaps retained rights to the product after all and are continuing to manufacture it in their Italian plant. I guess the best way to find out is to go straight to the horse’s mouth, so later today, I’ll try to give BMS a call and see what I can find out ;-).

    So stay tuned...

  5. #5
    Join Date
    Feb 2019
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    Spring Valley, Il
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    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Hey Marianne......thanks for doing the deeper digging for me..for all of us! Iím so tired and donít even want to get out of bed but I know I have toó-my little baby Annie needs me and I have to give her the dreaded Lysodren today along with two antibiotics and the ďwhatever ď drug I canít ever remember. Check your personal messages whenever you have time ómaybe it will give you a nostalgic smile. Blessings,Karen

    .

  6. #6
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    Apr 2009
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    Georgia
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    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Well, I already got through to BMS, and they confirmed the divestiture of Lysodren to HRA Pharma. So any bottles marked BMS are just holdovers from previous manufacturing runs, and whether or not the cheaper pricing that I saw online this morning will remain indefinitely, I donít know. But at least for the moment, there still appear to be cheaper pricing options available if you hunt them out.

  7. #7
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    Apr 2019
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    3

    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    I called Bristol Meyers Squibb directly when I could not get it at Sam's Club or Walgreens and was given a contact at Direct Success. BMS stated they had divested themselves, also know as selling the drug off to a pirate. At first my cost went from $5.00 per pill to $7.00 per pill and most recently to $14.00 a pill. When I called Direct Success about the price increase, they stated that the manufacturers, which is Direct Success, had a new "pricing schedule". Then he stated shipping was free!!!! At $420.00 for 30 pills, they should come to my house and administer the drug to my dog three days a week.

    I am not sure where these online suppliers such as chewy.com are getting Lysodren from unless it is old stock at the old "pricing schedule". If anyone knows a more economical place to obtain the drug, let me know. I do not care where I can buy it from as long as it is affordable.

  8. #8
    Join Date
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    Georgia
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    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Yes, I suspect the lower prices are associated with hold-overs from the BMS manufacturing runs. However, I guess you might as well take advantage of the pricing for as long as possible. If you just Google “Lysodren,” pharmacy options will come up for you. You do need to be very careful about purchasing meds off the internet, but all the specific internet pharmacies we’ve discussed today hold certification as “Safe Sites” through the National Association of Boards of Pharmacy, an interstate professional organization. This link tells you more about the certification, and shows you how verified pharmacy websites can be identified:

    https://safe.pharmacy/

    Of course, you don’t want to buy any medication that’s older than its effective date, so you might want to check with any pharmacy that you might order from, to make sure that any hold-over BMS product is still in date.

  9. #9
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    Mar 2009
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    rural central ARK
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    Default Re: Lysodren at $14.00 a tablet, 3 times a week

    Hi and welcome to K9Cushing's!

    Check out Diamondback Drugs. They are a compounding pharmacy which means they make dose sizes that are not offered by the manufacturers. Since Lyso only comes in 500mg doses they could make your baby a 495mg or 505mg dose for example that may be cheap enough to be worth the dose change. If memory serves they can compound doses 2mg either side (+ or -) of the available dose from the manufacturer. Here is a link where you can get a quote from them. Of course, you would have to get your baby's vet to submit a prescription for the new dose but hopefully they will be willing to help you out.

    https://www.diamondbackdrugs.com/get-a-quote/

    Hugs,
    Leslie
    "May you know that absence is full of tender presence and that nothing is ever lost or forgotten." John O'Donahue, "Eternal Echoes"

    Death is not a changing of worlds as most imagine, as much as the walls of this world infinitely expanding.

  10. #10
    Join Date
    Apr 2019
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    3

    Default Adrenalectomy - our experience

    Our 10 year old lab was diagnosed with cushing disease when she was nine. We managed with Lysodren for her first year. Our vet kept pushing us to have the surgery to provide her a better quality of life although I thought she was managing ok. Spoiler alert - our dog had to be euthanized 4 days post surgery.

    We found a local vet, not our regular vet, that had experience with adrenalectomy surgery. We did an consultation and he stated she appeared to be a good candidate for surgery. The vet did blood work that he said indicated nothing that concerned him and the next step was an ultrasound. That indicated one adrenal was enlarged and need to be removed. Still he indicated she was a good candidate for surgery so we scheduled it.

    Our dog was supposed to come home the day after surgery but the vet decided to keep her another day as she was slow to recover. Two days after surgery we picked her up. She would not eat and drank very little, they said she was depressed. Warning - when a vet tells you your dog, that would eat cat poop, is not eating because she is depressed, they are not telling you the truth. Our dog seemed confused and not all there. She did recognize the car and we took her home. She was not active and drank very little and would eat nothing even though we gave her a buffet of her favorite foods. Two days later, on a Sunday, we contacted the vet's office where she had surgery, the answering service stated they were not open and we should find a vet open on Sunday. We finally found a vet on a Sunday morning and they did some test and said to take her immediately to a 24 hour animal hospital about 45 minutes away. We took her to the animal hospital and after waiting a couple of hours, got her admitted. During all this time our dog was very lethargic. The vet at the animal hospital reviewed all the test results and stated her condition was guarded. Definition of guarded condition - very little to no hope of improvement. We checked in several times on Sunday and her condition did not improve.

    The next day, Monday, we contacted the vet that did the surgery and he contacted the animal hospital. Back and forth it went until Monday afternoon when we contacted him and he stated it was "futile" to continue treatment at the animal hospital. The word, "Futile", rang in my ears like a gun shot. How did it go from our dog being a good candidate for surgery to futile try to keep her alive?

    The worst was yet to come. We made arrangements with the animal hospital to euthanize her Monday evening. We arrived and were put in a small room off of the main area. We waited in silence for what seemed like an hour. Two techs and a vet finally wheeled her in on a gurney, she could not walk. She did not recognize us and never raised her head to look. She was spasming and had trouble breathing. It was heartbreaking. I kept thinking, what have we done, what have we done. I remember saying I was so sorry to her. Finally I could not take seeing her in this condition and called for the vet to put her down.

    So to all of you who are considering surgery for your beloved dog that has cushings disease, let this be a cautionary note that not all end well. Ours ended horrifically. It has been three months now and it still brings tears to my eyes to remember her like that.

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