Welcome to you and Wayne — I am SOOOO glad you’ve found us! We surely understand your worry, and we’ll do our very best to support you both. Upon saying that, I regret that I don’t have much time to post a comprehensive note right now, but I’ll do my best to return by tomorrow and write more. In the meantime, here’s a couple of quick thoughts. It seems very possible to me that Wayne may have developed an acute urinary tract infection. Cushpups are very vulnerable to UTIs, and that could definitely account for the blood in his urine. So your vet may want to check his urine tomorrow and even just go ahead and start him on a broad-spectrum antibiotic based on the assumption of a UTI, while awaiting a culture.
In the meantime, I agree that it’s wise to discontinue the trilostane until you have the chance to consult with your vet tomorrow. Can you tell us how much Wayne weighs? Unless Wayne is a really big boy, 120 mg. may actually be a higher dose than he can comfortably tolerate. Initial dosing recommendations have really shifted downwards during the last ten years, and the most widely accepted recommendation now is to begin at a dose that does not exceed 1mg. per pound. So if Wayne weighs less than 120 pounds, he might benefit from a lower dose to begin with. Here’s a link that helps explain the reasoning for this.
http://www.k9cushings.com/forum/show...=1251#post1251
I noticed in another reply that you are concerned that you have been handling the capsules even though you are pregnant. It’s very true that your vet should have cautioned you about this, but I cannot imagine that you have really exposed yourself to a genuine risk after only a couple of days. From now on, though, it would undoubtedly be best if you wore some plastic/rubber/latex gloves while handling the capsules. And for sure, do not open the capsules and expose yourself to the powder either by handling or inhaling it. To be on the truly safe side, you may want to contact Dechra, the maker of Vetoryl, directly in order to see whether they have any other precautions that they would suggest to you in terms of future handling.
OK, I’m afraid I’ve got to run for now. But please don’t give up hope for your sweet boy! Uncontrolled Cushing’s can definitely cause severe and distressing symptoms, but lowering the cortisol can result in enormous improvement. So let’s first see what the vet has to say tomorrow, and then we can go from there.
Once again, welcome to you both!
Marianne