Originally Posted by
Big Fish
Hi Lori,
Thanks for your response! I cut & pasted your questions to try to better answer:
Are the PU/PD and mildly elevated ALT the only symptoms your furbaby has?
He's a hound and hounds are ALWAYS ravenous so hard to judge(LOL) , he is however: lethargic, exercise intolerant (used to want to walk forever now puts on the brakes after about a block) , has had some weird spots of that pop up but then go away, no stair intolerance, has had unexpected weight gain of >10# (no diet change...even slightly reduced quantity) while I can see his ribs, he's not 'pot bellied' but his underline is definitely more flat across than previously tucked up.
Yep, those symptoms are common in dogs with Cushing's.
Has an UTI been ruled out for the cause of the PU/PD?
My vet put him on antibiotics for 2 wks to R/O a UTI. When SG was still 1.013, we did a urine culture that came back neg.
After we did the urine cortisol creatinine ratio screening test and it came back 78, my vet decided against doing the low dex test (b/c his adrenal glands were perfectly normal on ultrasound (done by a radiologist) , no enlargement, no growths). She recommended, which we just did, a full adrenal panel (ACTH Stim + sex hormone panel, sent to Univ. of TN endocrinology lab).
Sounds like your vet is on top of things which is wonderful, many GP vets are clueless when it comes to canine Cushing's.
Thank you for the paper referral on atypical Cushing's..I'll read it. It's all so-oooo confusing to me to sort out. I'm hoping this latest test will help clarify things. We've ruled out kidney disease, thyroid, vector borne bacteria, UTI so far. He's had some contrary lab results: i.e. normal ALP & blood platelets, etc, lacks some physical symptoms....so very frustrating! Appreciate your input. Thank you, , Debbie
80% to 90% of dogs have a steroid induced isoenzyme of ALP so if one of those dogs has Cushing's, you are gonna see anywhere from a mild to severe increase in ALP. Now, there is that 10%-20% of dogs with Cushing's and their ALP does not elevate that drastically, I have seen this situation a couple times on the forum, so it could be that your boy falls in that 10% - 20% group. I completely understand your frustration, Cushing's can be such a confusing disease that's hard to get one's head around.