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Thread: Proin

  1. #11
    Join Date
    Apr 2009
    Location
    Georgia
    Posts
    15,292

    Default Proin

    Quote Originally Posted by goldengirl88 View Post
    I respectfully disagree. If someone came to me and said they had a drug that would help Tipper's incontinence, but it could cause high blood pressure, stroke or heart attack, I am sorry but that is a deal breaker for me. It is everywhere that this drug is dangerous, but I have never seen anything saying it is safe, so that is indisputable to me.
    Patti, like you guys, I am seriously interested in getting to the bottom of the risks. But I have not found any research linking Proin with stroke or heart attacks in dogs. From what I have read, it can cause minor elevations in blood pressure so dogs with already higher levels probably should not take it. But I am not finding any veterinary medicine sites that say the drug is particularly dangerous for dogs who don't have pre-existing conditions associated with cardiac issues or high blood pressure. In fact, I've repeatedly seen the opposite -- that it is generally a relatively safe drug that can offer good results.

    I've seen hyperthyroidism and diabetes mellitus noted as conditions that can raise concern. And for the purposes of our forum here, I can imagine that Cushing's is not the best combo, either, due to risks of pre-existing hypertension. I can certainly understand why you would not think it a good choice for Tipper. But I am not seeing the blanket warnings that you and Leslie are speaking about. Can you give us some citations?

    Marianne

  2. #12
    Join Date
    Apr 2009
    Location
    Georgia
    Posts
    15,292

    Default Re: Proin

    I've just been doing some more searching and this is one of the more technical write-ups that I've seen of possible adverse side effects, including when used at therapeutic levels and also when the drug is overdosed. The possible side effects at therapeutic level pretty much mirror those in the earlier FDA link. When overdosed, apparently seizures are possible.

    http://veterinarymedicine.dvm360.com.../detail/755828

    Adverse effects can potentially be seen at therapeutic doses and include restlessness, urine retention, anorexia, tachycardia, and hypertension. Stroke-like clinical signs have been reported rarely in dogs at therapeutic doses of PPA.1

    The most common clinical finding of PPA toxicosis [overdose] is hypertension secondary to peripheral vasoconstriction. A reflex bradycardia can be seen.4 Other clinical manifestations of toxicosis may include piloerection, vomiting, tachypnea, anxiety or agitation, hyperthermia, tachycardia, tremors, and potential seizures.1

  3. #13
    Join Date
    Feb 2014
    Posts
    231

    Default Re: Proin

    My vet's office prescribed Proin to Pansy with the approval of the local IMS I saw prior to Davis. It had very little effect on her incontinence (night accidents and occasional overflow leakage) so I stopped giving it to her.
    “Generally, by the time you are Real, most of your hair has been loved off, and your eyes drop out and you get loose in the joints and very shabby. But these things don't matter at all, because once you are Real you can't be ugly, except to people who don't understand.”
    ― Margery Williams, The Velveteen Rabbit

    Pansy Lou Who, the Velveteen Boxer. Always loved, never forgotten. RIP 2014

  4. #14
    Join Date
    Mar 2009
    Location
    rural central ARK
    Posts
    14,549

    Default Re: Proin

    I need to find the FDA site Doc reported Squirt's reactions to...they are, or were, collecting info on Proin.
    "May you know that absence is full of tender presence and that nothing is ever lost or forgotten." John O'Donahue, "Eternal Echoes"

    Death is not a changing of worlds as most imagine, as much as the walls of this world infinitely expanding.

  5. #15
    Join Date
    Mar 2013
    Location
    California
    Posts
    4,435

    Default Re: Proin

    Hi gals,
    I know nothing about Proin. I am just thrilled to see Marianne posting! It is reassuring to know that she is still hanging out looking over our shoulders.

    GREAT TO SEE YOU MARIANNE! xxxxx

  6. #16
    Join Date
    Apr 2009
    Location
    Georgia
    Posts
    15,292

    Default Re: Proin

    Oh Kathy, you're a goof, but a very sweet goof!!

    On another note, I've got a cold and just pulled out my box of decongestant and found all the same exact warnings as for Proin...

    But it's pseudoephedrine, so hopefully the risk of stroke is "out," at least! Right now, I cannot breathe at all so that tablet is goin' down the hatch.

  7. #17
    Join Date
    Apr 2008
    Location
    Tennessee
    Posts
    6,593

    Default Re: Proin

    It is well known that reporting of adverse events for drugs, especially veterinary drugs, are grossly under reported. Volume of reported signs according to the FDA adverse events data for Phenylpropanolamine doesn't appear to be indicative of a problematic drug; however, numbers tend to be irrelevant if it's your dog that is having a bad reaction to a drug. I personally have had two dogs, both foster dogs, who did not do well on Proin and started acting like they had dementia within a week of starting treatment. I've polled many vets about Proin and all claim to have never experienced any problem with the drug. All we can do is educate ourselves on whatever drug we are going to put on or in our pets, as few vets, at least in my experience, never sit down with us and go over the list of adverse effects, what drugs are contraindicated, etc. The only drugs I've ever been counseled on are Trilostane and Mitotane and I firmly believe the only reason I received that counseling was because the vet was an internal medicine specialist. Here are the top signs reported to FDA for Proin:

    [Sign:] Vomiting Number of times reported: [10]
    [Sign:] Depression/lethargy Number of times reported: [8]
    [Sign:] Anorexia Number of times reported: [6]
    [Sign:] Convulsion(s) Number of times reported: [6]
    [Sign:] Ataxia Number of times reported: [5]
    [Sign:] Pressure Hi, Bld Number of times reported: [5]
    [Sign:] Polypnea Number of times reported: [4]
    [Sign:] Tachycardia Number of times reported: [4]
    [Sign:] Congestion, Skin Number of times reported: [3]
    [Sign:] Death Number of times reported: [3]
    [Sign:] Nervousness Number of times reported: [3]
    [Sign:] Pd-odor, Abn Number of times reported: [3]
    [Sign:] Sgpt/alt Hi, Bld Number of times reported: [3]
    [Sign:] Vocalization Number of times reported: [3]
    [Sign:] Anisocoria Number of times reported: [2]
    [Sign:] Confusion Number of times reported: [2]
    [Sign:] Creatinine Hi, Bld Number of times reported: [2]
    [Sign:] Diarrhea Number of times reported: [2]

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