Can someone please help me with Trilostane?

[molly muffin]

Good point, at the bare minimum a resting cortisol and preferably a full ACTH (but yea those are expensive)
Another thing we always talk about on here and see so much is that every dog is different and one reason to start out low is because you never know how a dog will react to Any medication. Some are quite a bit more sensitive to drugs than others. Some feel quite ill if their cortisol drop to low too fast too. We've seen big dogs end up on low dosages and little dogs end up on big doses, but you never know that going in unfortunately. None of the dogs ever seem to read the manuals.

sharlene and molly muffin

[BrendaW]

Hopefully she'll improve over night, but none in the morning and the vet needs to cut that dosage big time. He was right before when he said 1mg per 1lb, then blew it with this 57mg. grrrrr

I know you will sort him out though. Vets are there to help you and your furbaby. I know my vet wanted to start at 30mg, and my internal medicine specialist later said no that was too much. She is 19lbs.

Lori, do you think they need an acth test in the morning? Usually after a vomiting, the recommendation is that before starting back in on a lower dosage, you check to see where the cortisol is currently at. Especially with signs of a low drop.

Hang in there.
Sharlene and Molly Muffin

If this were me, I would definitely want to have a complete ACTH stim test done. I know how expensive those ACTH tests can be, so I would at least have a resting cortisol done.

Good point, at the bare minimum a resting cortisol and preferably a full ACTH (but yea those are expensive)
Another thing we always talk about on here and see so much is that every dog is different and one reason to start out low is because you never know how a dog will react to Any medication. Some are quite a bit more sensitive to drugs than others. Some feel quite ill if their cortisol drop to low too fast too. We've seen big dogs end up on low dosages and little dogs end up on big doses, but you never know that going in unfortunately. None of the dogs ever seem to read the manuals.

sharlene and molly muffin

Thank you both! I will call first thing in the morning. Thankfully, she seems to be doing better now, just a little weak. Hopefully, she will be even better in the morning. Thanks again for all the help and the support!

[molly muffin]

That's what we are here for, to support you on this journey that none of us every wanted to be on.

Let us know how things are going. We're a bunch of worry wart mother hens.
Hope both of you and can get some rest and have a good night.

Sharlene and Molly Muffin

[BrendaW]

That's what we are here for, to support you on this journey that none of us every wanted to be on.

Let us know how things are going. We're a bunch of worry wart mother hens.
Hope both of you and can get some rest and have a good night.

Sharlene and Molly Muffin

Thank you. I hope you have a good night as well!

[Meg_Elizabeth]

Loose stools or incontinence if the dose is too high.

[tarpola79]

Hi. I'm brand new here and my baby girl Sophie (12 year old poodle) has just been diagnosed with Cushing's Disease.

The vet has given her Trilostane at 57 mg. She weighs around 20 pounds (overweight, I know). I know very little about Cushing's and Trilostane but this sounds like a high dosage to me, based on what I'm reading. Does this dosage sound right to you?

There are several things that have happened and I'm becoming paranoid and a little scared. I don't want to hurt my dog!

Please help me if you can. I need to start her on this medicine today. Thank you!!!

This amount seems WAY too high. My dog was diagnosed with Cushing's last June (Michigan State Vet Clinic) and they got him regulated on 10mg of Trilostane twice a day. He's been having some issues lately and so they did another ACTH stim test and his cortisol level was too low. So they reduced his Trilostane to 5mg twice a day. He is a min poodle and weighs 16 lbs. I would not give him that high a dosage. I would get a second opinion.

[Harley PoMMom]

Just popping in to see how you and Sophie are making out, let us know as soon as you can.

Hugs, Lori

[BrendaW]

Loose stools or incontinence if the dose is too high.

I'm not sure she has either of those, but she sure threw up a lot!

This amount seems WAY too high. My dog was diagnosed with Cushing's last June (Michigan State Vet Clinic) and they got him regulated on 10mg of Trilostane twice a day. He's been having some issues lately and so they did another ACTH stim test and his cortisol level was too low. So they reduced his Trilostane to 5mg twice a day. He is a min poodle and weighs 16 lbs. I would not give him that high a dosage. I would get a second opinion.

Sophie is a min poodle too. I hope your baby is better!

Just popping in to see how you and Sophie are making out, let us know as soon as you can.

Hugs, Lori

Thank you for checking on us!

Sophie threw up a lot on Friday night. I held the Trilostane and called the vet Saturday morning. I actually have a better relationship with the on-call vet who I got to speak with. I told her the symptoms Sophie was having and she suggested we add an anti-nausea drug to the Trilostane. I told her I was reading that the dosage was too high and asked if we could lower it. She looked it up in her drug book while I was talking to her and said no, that's the right dosage for a 20lb dog. Looking back, I wonder if her drug book is out of date? She suggested that perhaps I was confusing pounds with kilograms in figuring the dosage. Also, due to the possibility that something else could have been causing the nausea (food, etc.), we agreed to hold the Trilostane until today (Monday) and restart it. Sophie's symptoms went away when I stopped the Trilostane and if she has nausea again I will ask politely that her dose be lowered. If they refuse, I will take her out of town to another vet.

Thank you all again for being here for us with all of this!

[Renee]

She looked it up in her drug book? Wow. It seems to me that Dechra is quite clear about dosing, with 1 mg per 1 lb as the starting dosage. Even though you are using compounded trilostane, the vet should still be able to at least access Dechra's product materials, or do a little more research than just reading a drug book.

[BrendaW]

She looked it up in her drug book? Wow. It seems to me that Dechra is quite clear about dosing, with 1 mg per 1 lb as the starting dosage. Even though you are using compounded trilostane, the vet should still be able to at least access Dechra's product materials, or do a little more research than just reading a drug book.

You know, they never even gave me a patient insert with this medicine. It says C-Trilostane 57mg. There's no mention of Dechra on the label. Just Pet Health Pharmacy.