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Thread: New to site--Lysodren (Calcinosis cutis)-sweet AnnaBelle has passed away

  1. #21
    Join Date
    Aug 2012
    Location
    Dallas, TX
    Posts
    880

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    HI Crystal..

    welcome to you an Annabelle. I also am a BT mom who has Cushings. I have not experience the CC with my dog. But, I know there are several on her who have. So sorry you are having to experience that.
    I hope you get some good advice from the others on here. I know some have used different herbal type stuff along with the meds to sooth the skin.
    We are all here for you.

    hugs..
    Amy
    Amy & my sweet boy Boriss (Cushings Diagnosed 8/30/12 & Trilo start 20mg 9/8/12 switched to Vetoryl 30mg 10/8/12)
    Grateful for every day I have with my baby Boriss. I am lucky to have so much love in my life.

  2. #22
    Join Date
    Apr 2009
    Location
    Papamoa, New Zealand
    Posts
    543

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    Hi Crystal,

    Welcome to you and Annabelle.

    Our Hungarian Vizsla, Sabre, had calcinosis cutis and was treated with Lysodren. The scabs will unfortunately come off if they are knocked or the dog scratches them. We put a T-shirt on Sabre ... we also allowed time without it to let the air at any scabs. Will Annabelle tolerate a t-shirt or a jacket on her?

    Angela and Flynn

  3. #23
    Join Date
    Jul 2013
    Location
    Pittsburgh, PA
    Posts
    173

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    I'm so annoyed. I STILL have not got AnnaBelle's records faxed to me...I've been asking everyday since Monday.

    And, I spoke to the vet this morning, and they want to do a one week wash from Trio to Lysodren. Isn't it supposed to be 30 days?? Not only that, since increasing her Enalapril to 10mg/day her protein is STILL going up. One month ago it was 6.1 and now it's 7.7. What could be causing her protein to continue to rise? She also lost 2 full pounds in less than a month.

    I just don't know what to do....I'm scared of the one week washout, but what if don't comply and do a 30 day wash out.Will this mess up her intial induction dose of 1/4 Lysodrene every 12 hours??

    I'm on the phone with the Internal Med Vet's office begging for her test results to be emailed or faxed.

  4. #24
    Join Date
    Apr 2010
    Posts
    7,965

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    Most of the endocrinologists will tell you it is a 30 day wash out when changing from Trilostane to Lysodren or vice versa. However, Dechra (manufacturers of Vetroyl-name brand Trilostane-tells the vets that it is only a 30 day wash our when switching from Lysodren to Trilostane, not from Trilostane to Lysodren. My speciaist called them to clarify about a month or two a go because she was proposing no wash out and a switch - I had a fit so she called.

    I reviewed Dechra's instructions and they do not say a wash out when switching from Trilostane to Lysodren. So it is a quandry as the specialist do recommend it.

    At this point, could you travel to the clinic and ask in person for your tests? Would that be an option?
    Last edited by addy; 07-05-2013 at 08:42 AM.
    love,
    addy, zoe and koko


    My little dog - a heartbeat at my feet. ~Edith Wharton

    Memory is the power to gather roses in the winter

  5. #25
    Join Date
    Mar 2009
    Location
    rural central ARK
    Posts
    14,549

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    There is no way under the sun that I would allow a switch EITHER way without a 30 day washout - either from Trilo to Lyso, or Lyso to Trilo. And I wouldn't give a flying flip what Dechra had to say about it - it's my baby, not theirs, who would suffer if they are wrong. PLUS each of these babies is unique and just because 50 other dogs didn't have a problem that does not mean mine wouldn't. It just wouldn't be worth the risk to me.
    "May you know that absence is full of tender presence and that nothing is ever lost or forgotten." John O'Donahue, "Eternal Echoes"

    Death is not a changing of worlds as most imagine, as much as the walls of this world infinitely expanding.

  6. #26
    Join Date
    Jul 2013
    Location
    Pittsburgh, PA
    Posts
    173

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    They said they are faxing right now. Hope to post soon.

  7. #27
    Join Date
    Jul 2013
    Location
    Pittsburgh, PA
    Posts
    173

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    Ok, I just emailed her entire chart to K9Cushings. Hopefully it will give you all a little more insight.

  8. #28
    Join Date
    Apr 2010
    Posts
    7,965

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    Just to clarify- I am not suggesting you do not do a wash out period, I am only explaining why your vet said none was needed.

    Having said that we did have a member switch without a washout period and that dog did not have a problem.

    Just providing information.
    love,
    addy, zoe and koko


    My little dog - a heartbeat at my feet. ~Edith Wharton

    Memory is the power to gather roses in the winter

  9. #29
    Join Date
    Jul 2013
    Location
    Pittsburgh, PA
    Posts
    173

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    I run out of Trilostane on tomorrow, and they want me to start the Lysodren 7/21, so I'm not listening to my vet, and that will give her a 2 week wash out, which makes me feel better than just a one week.

  10. #30
    Join Date
    Apr 2009
    Location
    Nebraska
    Posts
    5,606

    Default Re: New to site--Trilostane/Lysodren (Calcinosis cutis)

    I checked the dosage on the lysodren so please confirm I got the facts right. She weighs approx 15 lbs so the max per day she should get (to start) is 340 mgs. You are to give 1/4 a pill twice a day or 1/2 a pill daily. 500 x 1/2 = 250 mgs so you are below the high end of dosing. I think that is a good place to start. You may end up having to increase the dose but it's a good recommendation imo.

    Kim

    Here is a link to loading with lysodren that is very important.

    http://www.k9cushings.com/forum/showthread.php?t=181

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