The most common endocrine diseases associated with megaesophagus are hypoadrenocorticism and, possibly, hypothyroidism. With hypoadrenocorticism, it is suspected that megaesophagus results from impairment of muscle carbohydrate metabolism due to glucocorticoid insufficiency. In addition, depleted muscle glycogen stores and decreased catecholamine activity may play a role. In one case report, atypical Addison’s disease was diagnosed and subsequent therapy with prednisone resolved the megaesophagus.