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I hope I got the math right, Addy. That is not one of my strong points! :o Hopefully someone with better math skills will double check us on that!
If 250mg a week is right for her, then she'll only need 4 tablets a month. Can they prescribe that few or will we have to get 30 tablets? Guess I will have to ask them, huh?
Now, where is the best place to get Lyso via the web?
Hi Leslie,
You got the math right on determining the maintenance dose, however, your accounting for pills needed per month is incorrect. At 250mg per week, one 500mg pill is good for two weeks so you will only need two pills a month. Your vet should be able to prescribe whatever amount you want.
I looked on line and found some places that compound it with different dosing choices so you would not be limited to 250 mgs.
Did you not want to compound? They had flavored liquid suspended in oil and capsules for a lot of different dosing choices.
I knew the Trilostane was compounded but did not remember reading much about people using compounded mitotane.
Just wondering for you and me. 250 mgs for Zoe comes out to something like 32 mgs per kg.
Just started looking at pricing. Hopefully someone will have some info.
Hugs,
Addy
Hugs,
Addy
Both Lulu and Jojo are on compounded mitotane which I get from Diamondback Drugs. Small dogs requiring doses less than 125mg (1/4 lysodren pill) usually have to have their dose compounded.
Thanks, Glynda! I figured I would have made a mistake somewhere but that was a simple one! :o Should have used the calculator to determine the number of pills per week....geez!
I found where I can get the compounded Lyso but since 250mg will work for her, then I plan to simply give her 1/4 pill 2x/week. If this works, then I won't need to get a compounded form.
Just before Christmas, I got robbed - my pre-paid debit card was wiped out by someone playing games online to the tune of $1500+. :rolleyes::mad::( That was Squirt's testing money, Trink's surgery money, plus Christmas money. With that gone, I can't have her tested before starting the Lyso. I know the Lyso will address all the hormones that are still elevated and/or rising, while the lignans and melatonin seem to have done their job with the estradiol, bringing it back to normal. This makes me a bit nervous even tho I really think it is time she starts the Lyso.
The signs I was seeing have abated some but are still present at times. The increase in melatonin and/or the PS may be having an effect, reducing the strength of the signs but with her cortisol steady rising and the andro so high I worry about long-term damage. She has been through enough - I don't want kidney, liver damage or diabetes to develop. She has had a great run for nearly 3 years all things considered but now she needs a bit more help.
I'll keep ya'll posted as we move into this phase of our journey.
Hugs,
Leslie and Squirt
Hi ya'll,
Squirt will start her maintenance schedule in the morning at 125mg. I plan to give her the second dose on Sun. morning.
Which brings me to a question I have wondered about for quite some time now. Why isn't maintenance set up to be given every 3rd day regardless of where in the week that falls? Would that not give a more uniform coverage instead of having two days and then three days then two days and so forth between doses? It would be more difficult to keep up with so that may be why.
Hugs,
Leslie and my Sweet Bebe
I give Casey her dose every 3 1/2 days so Monday morning and Thursday night. I also have a calendar that is strictly hers so that I can keep track of her Lysodren dosing days, Adequan injections etc.
Hope this helps!
Leslie, why do you have to ask such difficult questions? :D It is easier to keep track of if you simply choose set days of the week to dose. Sounds like you have picked Wednesdays and Sundays which sounds like a good plan to me. My two dogs get three doses per week on Mon, Wed & Fri. There is no doubt in my mind that I would screw up everything if I tried to dose every three days, plus they would not be getting their entire maintenance dose within 7 days. Dr. Feldman says because it's cumulative, it doesn't matter which days you choose as long as the dog gets the total "weekly" dose.
Thanks, Glynda! This old brain of mine often ponders crap! :p
Squirt had her first dose of Lyso this morning in 1/2 tsp of peanut butter. Like a dummy, I crushed the tablet portion in my mortar and some of it stuck to the bowl and pestal but I'm sure she got enough. There was just a fine dusting left on the bowl and pestal but Sun. I will try to get it down her whole...well 1/4 of the whole anyway. ;)
She has become very much opposed to taking pills the last few years so I am going to have to find some new tricks. She will no longer eat American Cheese or cream cheese as she is sure there is a pill hidden in there somewhere - and there was for a long time! I have tried wrapping pills in deli meat, covering them with butter, and the "never-fail" pill-pockets - wrong! Little huzzy will absolutely refuse it all! :rolleyes: ONE thing that may work is giving Trinket something at the same time...but then, what can I give Trink that won't set her colon off? Fun times in the camper to come! :p Yep, yep! I see margaritas and valium in my immediate future! :D
Hugs,
Leslie and Squirt
You can take some of the cooked meat you feed Trinket and put the pill inside the small piece of meat and then give it to Squirt. You could first give Trinket some pea size pieces of the whitefish so Squirt is envious.:cool: Trinket's colon should not be bothered by the same cooked meat she is eating for her meals. I smush the meat around the pill so you can't see it. It doesn't take alot of meat (fish). Would that work?
Zoe can only have turkey so we cook a turkey breast for all her treats and I hide pills inside a very small piece of that meat. Her treats are only cooked turkey breast, we freeze slices and defrost a slice for a few days. I feed Koko the same meat as his treat. You could just cook up some fish and save alittle for a treat reserve.:)
Hugs,
Addy