With Molly having kidney stones I don't know how accurate an UPC would be, wonder if Molly's IMS would know?
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With Molly having kidney stones I don't know how accurate an UPC would be, wonder if Molly's IMS would know?
Sharlene, I have only a moment to post right now, but I don't think Molly's baseline results would explain the lack of overt symptoms. Many symptomatic dogs have baselines that fall within normal range (and conversely, many normal dogs may have elevated baselines if they are stressed during the testing), and that is why baseline cortisols are useless in terms of Cushing's diagnostics. It is only the stimulated result that is meaningful in terms of differentiating dogs with hyperadenal activity.Quote:
It is interesting in that she doesn't ever seem to have high levels in her body, only in the adrenal glands, her base has been within normal limits and that is likely why we don't see symptoms, it doesn't appear to be dumping until an ACTH is done. My vet said, molly remains one of the more constant mysteries to her, and both the IMS's that have seen her. To look at her, she looks fine, other than the knee and hip, which is actually both part of the same problem. (years of over compensating on the one side for the other side, has likely been the cause of the knee issue)
Marianne
Well .... fooey! LOL My vet is actually the one who mentioned the low baseline, but I did point out that the posts were still high. (don't think she looked that over before calling me)
We're heading out for yet another dinner for hubs birthday. This is his third one this week, all with different groups of people and I need to check and see if he is up for a greek buffet luncheon tomorrow before we had downtown tomorrow night for the theater and "We Will Rock You" it's getting good reviews in Londan (UK) and I can't wait to see it.
Molly got the SO for breakfast and we had the not so great poop this afternoon. This morning after last night having some of the Fromms, she had perfect poop, it is definitely a food/gastro thing I think we can safely say.
got to run
hugs all
sharlene and molly muffin
That's great you figured it out, I have been feeding my boys Fromm for a few years, it is excellent food and family run. Happy Birthday to your hubby! Enjoy your celebrations :)
Have a nice dinner out Sharlene and Hubs, Happy Birthday to him. Is it the Japanese restaurant tonight?? Yum!
Glad you have the cause of the bad poops narrowed down, sounds like it is under control! Yay Molly!! xx
My brother says that we don't have birthdays, we have birthday weeks. :-)
Mine was yesterday. Happy birthday to hubs!
Well heck Happy Birthday Valerie! :) We do birthday weeks too, sometimes months even, as things drag out and different people can get together at different times.
I love to make hubs laugh when I am still calling him the birthday boy. :)
Yep, Japanese tonight, tomorrow Greek and then the theater.
I really hope to rest on Sunday, going to need it, but hubs has mentioned opening the pool!! ack! Course then there was the mention followed of carribean rum punch, so maybe we need to hurry and get it open. LOL
Molly loved having everyone around this evening after the dinner out. She didn't even bark at everyone coming in, just popped right over and said hello. Who is this dog, she normally barks at everything!!
Oh she had that front paw act up right before we left today. Hubs said he thinks that it fell asleep on her. I massaged it a bit, I put her down, he gave her a treat and she continued to hold the paw up, then took off on it, with a bit of limping and then was fine.
got to run, exhausted here!
hugs
Sharlene and molly muffin
Rum punch sounds delicious!!! Get that pool open :) Hope Molly's is doing well. I see she likes to be as difficult as Kaibo. Why don't they play by the rules already? Don't they know what they are doing to us? :eek: Just stopped by for a quick hello! Take care. Nikki and Kaibo
Sharlene:
Glad you had a good time out for your hubs birthday. He sure had a lot of celebrations which sounded nice. It is dreary here this morning and I don't want any more thunder. I am not feeling well this morning so I am taking it easy. I have Leslie and Squirt burned into my brain, and it keeps playing like on a loop. This has really shaken me. It puts you one step closer to you own babies mortality. I hope Molly is settled down with the poops?? Wonder what is up with that? Have a good weekend. Blessings
Patti
Hey Sharlene, I wanted to come back and add a better explanation about the baseline cortisol info. Here's a quote from Dr. Peterson that gives more detail:
http://www.researchgate.net/profile/...cf3ee6045e.pdfQuote:
Basal cortisol concentrations, when used alone, are not reliable in the diagnosis of hyperadrenocorticism in dogs. Because of the episodic nature of cortisol secretion in dogs, basal cortisol concentrations fluctuate throughout the day, resulting in a high degree of overlap of values in normal dogs, dogs with nonadrenal illness, and dogs with hyperadreno-
corticism.1-4,17,18 The sensitivity of basal cortisol determinations in the diagnosis of hyperadrenocorticism is only about 0.5 (approximately 50% of dogs with the disease have high random cortical concentrations), whereas the specificity can be extremely low in dogs with severe nonadrenal illness. This severely limits the usefulness of basal serum cortisol concentrations in the diagnosis of hyperadrenocorticism. Plasma or serum cortisol values are only useful after dynamic stimulation with ACTH or suppression after dexamethasone.
I know you're looking at the baseline in terms of symptoms and not purely diagnostics, but I'm guessing the same explanation would be involved. Since Molly's stimulated reserve is abnormally elevated, it is likely that there are indeed times (like when she is excited or stressed) when the cortisol release throughout her body is excessive. You've just not been catching those times on these baseline draws. As to why she does not evidence overt symptoms from this, I remain clueless but grateful!
Marianne