Re: Opinion on Dr. Plechner theories?
Thank you so much everyone for your replies. I hear what you are saying, I do. I guess the issue i am struggling with is that in my dog's atypical cushiness, his cortisol is normal. His estradiol is extremely high, baseline is 145. Post-stim, the estradiol went down to 122, which I find interesting. It does appear that this is the case in most of the posted test results, am I correct? Anyway, in my dogs case, the diagnosis is essentially that the intermediates and not the cortisol are high. My understanding is that the reason this is called "atypical CUSHINGS" is that the high intermediates mimic the symptoms of high cortisol. So it is technically like a "pseudo"-CUSHINGS. There has been a connection established in SARD dogs that they largely have high estradiol levels (hyperestrinism)- not specifically atypical CUSHINGS, ( since atypical CUSHINGS could mean many different things in terms of elevated intermediates, not necessarily high estradiol). But high estradiol levels seem to be linked to SARD. Some SARD dogs are later diagnosed with CUSHINGS, be it typical or atypical. This is the connection that concerns me. PLEASE correct me if I am wrong about this, I am just wanting you to understand where my concern is coming from I am not arguing with you. I need you to keep talking to me because no one else has the knowledge that you do. Please write back!
Re: Opinion on Dr. Plechner theories?
quote from one of dr oliver's papers- " *Steroid profiles have also helped to better understand the condition of SARDS in dogs, where steroids other than cortisol frequently are involved."
Re: Opinion on Dr. Plechner theories?
Here is a link to Dr Oliver report on this, you will see why i am concerned....
http://www.jaaha.org/content/45/5/207.abstract