Tipper - adrenal tumor/breathing issues

Hi Patti

As you know Teddy has the same high red cells as Tipper
and he has had Low Whites as you know also.

I know it was mentioned to you about a bone marrow test
as it was for Teddy, that is the only way you can tell for sure
if they have Bone Marrow issues.

BUT it is not something that we all want to put our little ones through. It needs a general anesthetic in many cases, and is painful in many cases.

I hope you can find out another way, as yet I don't know if there is one that will tell you.

If you find one, please let me know too.

Diana x

I think I would call Dechra and see if they have any input on that for you. Interesting thought....

Patti, per Dechra's Treatment Brochure, they say that trilostane can cause red blood cells to decrease, but not to fall below normal range. To my feeble brain, this would also point to low reticulocytes, too, but maybe not. Maybe there is some paradoxical effect that causes them to increase. I agree with Leslie -- this would be a good question for them.

Quote:

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Complete blood counts conducted pre- and post-treatment revealed a statistically significant (p <0.005) reduction in red cell variables (HCT, HGB, and RBC), but the mean values remained within the normal range.

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Marianne:
I am going to call Dechra in the morning and ask if they know anything on this. Good idea Leslie. I guess I would have thought to do that, but in a way I am asking myself if I really want to know this????? Blessings
Patti

Patti,
Hugs and love to you and Tipper.

Interesting Patti, I'm curious to hear what they think.

Hi Everyone:
Well we woke up to a beautiful 4-5 inches of snow. It is so pretty outside and the sun is shining and glistening off the snow. Tipper walked and is so happy and energized it is unreal. She just loves this stuff. I have to keep her from wanting to rub her ears in it though. Last time she did that we got an ear infection. I am waiting until someone is in at Dechra this morning before calling to get info. on the bone marrow stuff. I have an appointment to see the Urologist Monday the 18th, which would have been my brothers 65th birthday had he lived. My insurance company gave me bad information when I had to have all my testing done in Pittsburgh, because they said the hospital this Dr. goes to is not in network. So I could have gone there all along! I just received my benefits package from work. They have gone to even cheaper insurance, and dental. I need to get this stone out before the end of the year as I have all my deductible paid. When I worked my company was written up as having the best benefits in the US, now it has really gone down hill. Tomorrow Tipper gets an Adequan shot and she needs one, she has been a little noisy lately, and doing all that continual swallowing. Yesterday I gave her one of the allergy pills from the IMS, It seemed to help a little, hard to tell sometimes. I will post after talking to Dechra. Blessings
Patti

All this talk about snow! :cool::cool::):cool::cool: That is one of the things I really have been hoping Squirt gets to experience again because she so loves the snow! She will put her face down in it and plow! :p

I told one of the techs about Dr. Smith's use of Adequan and plan to talk to Doc B today and see if he has or will talk to Dr. Smith and start this for Grace. I hope we can do this for her and that it helps her. I may end up running her through the rescue I work for and using Dr. Smith but that would mean driving to LR every week but the difference in the cost of the shots may make that worthwhile - I'll have to see.

Really looking forward to hearing what Dechra has to say about the med's effect on bone marrow!

Leslie:
Tipper just went out potty and jumped in a pile of snow I had swept away so she could go. She is having a ball. I am hoping that the Vetoryl is not causing Tipper's problems, but we will soon know as I am calling now. Blessings
Patti

Hi Everyone:
I just got off the phone with Dechra. I was told that they have no evidence that Vetoryl would be the cause of Tipper's high Reticulocyte count. I got to thinking about that though when we were on the phone I was looking at my spreadsheet of Tipper's HGB and HCT and Reticulocytes. I am wondering if it could possibly be the Vetoryl and they just do not know it yet. The reason I thought this was Tipper's last blood test showed her cortisol was up a little, and her Vetoryl dose was lower at that time. I am going to go thru her dosage changes and ACTH tests and see if I can find a connection that way. I want to see if during the uncontrolled periods her readings were lower or higher on the HGB,HCT and Retics, and when her cortisol dropped real low, if these numbers were higher or lower. I could possibly find a pattern to establish what could be the root cause. I will have to study these today. One good thing I usually always have a blood panel when doing ACTH so it will be easy to compare . So I guess it still remains a mystery until I unlock the secret. Blessings
Patti