Introducing Fraser - our sweet Fraser has crossed The Bridge

Thanks guys, I will definitely check these out. As for fish, he will eat it sometimes (on his terms of course) Pork is his favourite (after ham of course, but that's only for pills, and a tiny amount at that). But for a country surrounded by water, fish can be horrendously expensive here. Mind you 50% of that is just because it's Perth. It's a well know fact here that to go out for dinner, what you would pay $10 for in Melbourne, will cost $30 or so here. We have been officially labeled as one of the top 10 most expensive cities to live in in the world. :eek:

But still, blood test results and my worry not withstanding, he obviously still feels ok. Was busy chasing his Kelpie girlfriend around the park again last night. :p I asked the specialist about that - she's never heard of it before (as in a neutered male going for a neutered female), and the fact that he is so specific that he will only go after working dogs gave her a laugh! I think that's what has hit me so hard with this news. I really wasn't expecting it! Thought he was doing great! :o

Hi Naomi,
I have been following your thread ever since you messaged me about being a teacher and needing time off sometimes to taken care of Frazier and get testing done. You helped me to be able to put it all Into perspective, so thanks again.
Anyway, I'm glad to hear that Fraser is doing better. At least he's chasing after girls that have jobs! Ha:D

Kathy and Buddy:)

Hi Noami, I am happy Fraser is doing better. What testing did you decide on? Thinking of both of you.

Sharon

Lori found links to the diets I was talking about so you have that info here. Thanks, Lori!

So here's a question for you. What happens if a dog gets 5 consecutive days of double dose Denasyl?

I was giving Fraser his dose tonight and thought "these look smaller than the other ones" so looked at the dose on the back of the strip, 225mg. Went to look at the dose on the old strip, 425mg. :eek::eek: Partly my own fault for not looking I guess, but when I got the pack, there was 5 missing, obviously it's been opened and some cut off for somebody at one point, I just thought, "oh well, will tell them about that this week" but didn't look at the strength of the 5 on the cut strip. It turns out they were the high dose 425mg!

Question is, what effect could that have had on Fraser long term? (he had no obvious side effects over those 5 days) He has since been on the 225mg for 3 doses now, but now I'm worried!

On a progress note, he is still pretty bright, was very tired the other day and a bit down, but I think that was lack of his afternoon nap as he was good again the next morning. I am definitely noticing signs that he is getting old now though. He has lost qite a bit of muscle mass lately. His neck feels just like bone without much covering it, and I am now seeing his spine starting to stick out. He just doesn't necessarily look like he's lost a lot of weight, but if his liver is so enlarged (which I know it is, you pat his tummy and hear the hollow liver sound) he must have lost more than it looks. When he went to the vet last week, he had lost 1/2 kilo then, now the lightest weight he has ever been.

I'm ringing specialist on Monday morning to book the U/S. I just hope the extra dose of Denasyl hasn't compounded any problems! :(

P.S have now commenced 5mg bd trilostane. Long way from the original 60mg id! I'm even starting to wonder if he even really does have cushings! Seems a really low dose now!

Hi Naomi,

Denasyl is SAMe and it is generally very safe, even in high doses. Here is what one source has to say -

Quote:

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Safety

Denosyl demonstrates an exceptionally wide margin of safety. Oral acute toxicity studies in rats indicated an LD50 greater than 4,640 mg/kg.6 Clinically healthy dogs administered 20 mg/kg/day of Denosyl for 6 weeks and clinically healthy cats administered Denosyl at 2 times the recommended daily amount for 113 days remained healthy with no adverse effects from administration of Denosyl.

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http://www.drugs.com/vet/denosyl.html

So, I wouldn't worry over much about the dose mix up. ;)

I hope the testing goes well and shows no issues to concern you.
Hugs,
Leslie and the gang

Oh thank god for that! Thanks Leslie! I did do a bit of searching but the only thing I found was the standard "contact your vet in case of overdose" and I'm thinking, "well, it was three days ago, bit late to contact now". Just hoping it did more good than bad for his liver. :o

Guess it at least explains why the pills were so big!

HI Naomi
Woopsies!! Sounds like no harm done though phew! How much is that costing you over there? We were considering it for Flynn but his liver tests actually improved a little last check so it's on hold for now, but maybe on again in the future. Vet said it is real expensive.

Hope it helps Fraser's liver, scan results will be good to see whats happening. Pleased to see he is still his frisky self :D

Trish

It is very expensive! I just bought 1 oz of liquid SAMe for Squirt and it was $39 with shipping! :eek: But she only gets a couple of drops a day so hopefully it will last.

I've seen online prices for 225mg of Denasyl ranging from $140-80 AUD. thats for 30 tabs! :eek: Get this though, from the vet it was $20AUD! :confused: For 30 tabs! Will continue to get them from the vet in future! :D Just hope they are working!