We're waiting with you Patti, hugs.
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We're waiting with you Patti, hugs.
Hi Everyone:
Thank you all for your well wishes, you are getting me thru all this with your strength. Tipper had a good nite last nite, we both were exhausted and it was lights out early. Tipper even slept in 15 minutes late which she never does. It gave me hope yesterday when I read the post from the person that has kept their dog going for 3 years now on Trilostane. I am once again hoping for another birthday for my girl. I will be calling the vets office around 11am to see if Tipper's blood work is in, I am anxious to see it after all the tweaks I have done with her supplements etc. I will finally be able to let go a little and not have this knot in my stomach if the blood work is ok. It is really cool here this morning Tipper had to wear a vest to walk. It rained all nite and is going to start here again shortly. Tipper finally had a break thru and lost 2 whole ounces. I am not going to complain as any loss is good right now. I will be happy when my regular vet is back on the 21st. I will post as soon as I get the numbers. Blessings
Patti
Hi Everyone:
Well I have the results in hand and need some opinions as soon as possible cause you know me I want this under control yesterday. Tipper's post jumped from 3.0 to 8.3 and that is why I am seeing the hunger etc. The pre was 0.7 and went up to 1.5. Now here is the tricky part. I want to lower the post without lowering the pre too much. My though is this she is currently taking 20mg Vetoryl in the morning and 5mg trilostane at nite. She had previously been on 30mg Vetoryl in the morning until her pre dropped to 0.7 that is when they wanted the dosage dropped. Since 30mg is too much and 25 is too low, how would 20mg Vetoryl and 7mg Trilostane nboth given at the same time in the morning. I had given her the 20 Vetoryl and 5 trilo together in the morning and that was not enough she was starving at nite so they made me split the dose 20 and 5. SO I say 27mg all at one time in the morning. I would love and need some opinions. Do you think I should go to 28 with 8 being trilostane? THis is getting expesive as I just bought 90 of the 5mg trilo, now probably can't use them.
The other things I was worried about was the Alk Phos. it was previously 201 and is down to 150. The ALT had been 137 and is now 88. So I am grateful for that especially when the IMKS told me the Ursidiol would make no difference in Tipper's ALT. Well we know that not to be true, and I am so glad I listened to myself and put her on it anyway. The other value that I am still really concerned over is the Reticulocyte it was 129 now 128 but that is still high. It has something to do with new blood cells not forming totally, like in hemolytic anemia. Does anyone else have their blood report and have high reticulocyte? If so please let me know the numbers you baby has, I need to get this worked on asap. The rest of the blood report was good but the triglycerides are still thru the roof which is common for cush dogs. I am relieved, but must get on this cortisol lowering now. I could tell by the way she was acting that it had increased, and I kept saying about her moving around the bed at nite which seems to be a hallmark for it. Any and all suggestions will be appreciated so thank you in advance. Blessings
Patti
Just a quick note. I think you'll need to continue with the split dosage, but maybe tweak it a bit. What I would probably do is increase it in the evening, by adding to it as that is when she gets restless and hungry. Don't throw away a 5mg, you could order say 2mg pills or even 3mg to add to the 5, but I think leave the 20 alone in the morning, since we know that 30mg at one time takes her dangerously low.
It is harder with an adrenal tumor than a pituitary one I think, when it comes to management and dose tweaking seem to be the norm.
Are those ALT and ALP results in the normal range? or still high? No I don't have anything with molly having abnormal Reticulocyte.
hugs,
Sharlene and Molly Muffin
Hi Patti,
I agree with Sharlene on this one. Afternoon and evening seem to be the time when Tipper is the most uncomfortable. Once a day dosage will likely increase that, as her morning Vetoryl wears off. You might want to tweak it a little, but I wouldn't do away with her evening dosage all together. I think she needs at least some Trilo in the evening.
Do you still think that when her 30mg dose lasted her all day and there were no issues?
This is my think-so only, I don't know if there is anything to support this or not. But it seems to me since this drug is known to have such a very short life in the body and it is known that adrenal tumors are more difficult to manage medically, it would make more sense to try to keep an even amount of the drug in the system over a 24 hour period instead of a lot in the mornings and a little bit at night. In my simple mind, it would be better to have the dose more evenly divided AM and PM.
Again, this is just my whacky mind wandering down the corridors but it makes sense to me.
Sharlene:
The Alk Phos is normal but at the very end of normal the range is 10-150 hers is currently 150, it used to be 35 believe it or not. The Alt is normal also in the range of 5-107 with hers at 88. It is coming down with the meds.
Thanks Leslie I always take your information seriously as you really seem to have a knack for knowing what to do.
Kathy thanks for the input, it is helping me do the right thing here.
I called Diamondback and even though I have about 60 capsules of 5mgs of Trilostane left, it is just as cheap to order 7 mg. as it is 2mg. So that way I won't have to give her 2 pills. She will be getting 27mg a day and I think that will be where she needs to be without making the top number go too low. I talked to Dechra and the vet wants to talk to my vet, so my vet is out until Monday and I will take care of this then, I do not want to have to deal with the vet subbing for him. It is just better that way. I need to get a grip on this Reticulocyte problem. If anyone is familiar with it please let me know. I am going to have to get my vet researching it and find out how to correct this, I have looked but not found a whole lot of possibilities. It is pouring here again and the forecast sayd we go to the 40's next week. Tipper will be thrilled. Blessings
Patti
Patti,
We split Daisy's dose exactly in half so that she gets the same amount twice a day. This is the best way to go.
Hi Patti... just checking your posts and the test results. You know I can't help you at all.... but I still check to see how you and Tipper are doing.
Glad things went fairly well, and I know you'll do everything possible for your baby.