my 16yrs old baby Dau Ting (Trilostane) ~ passed away on 3May2011

[Mavis]

Hi, my elderly baby dog is 16 years old & just diagnosed with PDH Cushing by the end of Nov2010. Vet is giving her Trilostane on 30mg once a day.

ACTH test was showing in high levels at 11 times than normal, CBC blood test was stating the liver function is higher than normal almost 5 times, urination test is quite good (all negative) except the color has a little bit of undertone due to Cushing.

I would like to know it could be confirmed that she has had Cushing for just doing the above test? Actually, I found she lost hair, increased thirsty, increased urine, dark spots, potbelly a couple of years ago BUT weight loss, hind leg weakness & excessive hair lost since a month ago. It’s a most symptoms likes Cushing…

Since she was starting to take Trilostane a few days ago, there are no any side effects up to this moment.

I am worry about her right now. Due to nobody at home for monitoring her at daytime, I just can rush to home for monitor & take care of her after work!

Trilostane whether is the best treatment for her? Is there any serious sequela of Trilostane? As I know it will have another medicine named Mitostane, which one is better? Anyone could give me some advisement? What should I do for her right now & future?

As I study some article said that it just only 12-18 months survive & the first six months is most dangerous after treatment begins, is that true?

Next week my baby will go to take 2nd ACTH blood test, hope be fine everything…God Bless!!

[mytil]

Hi and welcome to our group.

Can you tell us what other tests were performed to come to this diagnosis? (and the results too). Cushing's is difficult to diagnose and really there should be several tests done. See this link for more of an explanation. http://www.k9cushings.com/forum/showthread.php?t=180

How much does your dog weigh?

The 12-18 mos. time frame is simply not true. Since a lot of dogs are diagnosed with Cushing's when they are already elderly, I believe these numbers to be skewed. We have members who have been treating for 3-4-6 years now.

I do not have personal experience with Trilostane but I have added this to your title so those who do will chime in.

Terry

[littleone1]

Corky and I also want to welcome you.

Corky was originally diagnosed with cushings about two years ago. Before we started treating it, his clinical signs went into remission for 7 months.

Corky has now been taking Trilostane for 14 months. His dosage has had to be adjusted a few times, and his dosing was switched from once daily dosing to BID. He is doing very well on the Trilo. Adjusting the dosage is not unusual. In most cushpups, the desired cortisol level will be reached, and they are able to stay on a certain dosage.

I hope you get good results with the Trilo.

Terri

[apollo6]

Welcome.
My Apollo is on Trilostane since June 2010. I am giving you a quick link on cushings, showing you the different kinds and how a dog looks and the tests needed. http://www.kateconnick.com/library/cushingsdisease.html


A blood panel a lone does not diagnose PH CUSHING. You would also do a ACHT Stim test( to show how much cortisone the body is producing) and an ultrasound would show if it is the pituitary or adrenal gland tumor type. If you read my thread the beginning you will see. Only once you know which cushing it is do you decide on treatment.
Hugs Sonja and Apollo

[Mavis]

My dog is 4.6kgs now (she maintain 5.5kgs for the past many years) that undertook CBC, urine & ACTH Stim test last week.

I’ve asked for the Vet whether confirms my dog is Cushing for just did the above 3 tests & they replied ‘YES’! That’s why the Vet who will prescribe Trilostane.

Also I’m asking for give me back all of copy of test for my record & follow-up by myself, I will post it when got the copy.

In Hong Kong, ultrasound & CT scan for animals are very expensive and not many place have the equipment could do that! Ultrasound around HKD4,000-6,500 & CT scan around HKD12,000-15,000 at referral center. So the Vet said most people wouldn’t let their dogs go to do such of further test.

For my baby, they said due to the 1st ACTH Stim test reflected in high levels (11times than normal), so the Vet suspect there is a tumor in brain (PD Cushing) rather than adrenal gland tumor. Due to its involve with head surgery as it is very complicated, so they let me make decision by myself. I consider my baby is old that she can’t take such of high risk!!

Next Wed (12Dec) my dog will do 2nd ACTH Stim test, CBC & urine test after the treatment started 11 days. The Vet said those 2nd test is to see whether effective on my dog for giving Trilostane.

Besides, my dog took a drug a week now & I found her drink less & urine less. Is it a positive effect? Will it rapidly come up the result? She’s good spirit, active & no bad appetite…

p.s. Many thanks for all of your support :)

[frijole]

Welcome! Yes, it is good that the water intake is less. It is a sign the drug is working. Here is more information that might be helpful.

Kim

http://www.k9cushings.com/forum/showthread.php?t=185

[apollo6]

You are doing a good job for your baby. The fact that the drinking is less is a good sign. And with Trilostane you can always stop if need be. We are here to support you.
Hugs Sonja and Apollo

[Squirt's Mom]

Hi Mavis,

It sounds like Dau Ting is doing well with her treatment so far. That is good news! The decrease in drinking and peeing is definitely a good sign, and having good spirits is great! :D Keep in touch and let us know how things are going for both of you.

Hugs,
Leslie and the girls :D - always

[Mavis]

Hi, I’ve got the 1st ACTH Stim test, CBC blood test & urine test & the 2nd test (in 11days of medication).

Here is the reports outcome:

ACTH Stim Test
24Nov10 Cortisol (by CL) 10.2ug/dL 282nmol/L
Cortisol 2 (by CL) 123.0ug/dL 3,395nmol/L

8Dec10 Cortisol (by CL) 6.5ug/dL 180nmol/L
Cortisol 2 (by CL) 33.0ug/dL 911nmol/L

CBC Blood Test
Results Ref Range
21Nov10 HCT 34.0% 37.0-55.0
HGB 11.2 g/dL 12.0-18.0
MCHC 32.9 g/dL 30.0-36.9
WBC 10.9 10 9/L 6.0-16.9
GRANS 7.8 x10 9/L 3.3-12.0
%GRANS 72%
L/M 3.1 x10 9/L 1.1-6.3
%L/M 28%
PLT 503 x10 9/L 175-500
Retics 0.3%
ALB 27 g/L 22-39 ALKP 1021 U/L 23-212
ALT 473 U/L 10-100
AMYL 661 U/L 500-1500
UREA 21.9 mmol/L 2.5-9.6
Ca 2.37 mmol/L 1.98-3.00
CHOL 6.84 mmol/L 2.84-8.27
CREA 111 umol/L 44-159
CLOB 30 g/L 25-45
GLU 8.15 mmol/L 3.89-7.94
PHOS 0.99 mmol/L 0.81-2.19
TBIL < 2 mmol/L 0-15
TP 57 g/L 52-82
Na 156 mmol/L 144-160
K 3.2 mmol/L 3.5-5.8
Cl 116 mmol/L 109-122

8Dec ALKP 731 U/L 23-212
ALT 281 U/L 10-100
UREA 17.9 mmol/L 2.5-9.6
CREA 83 umol/L 44-159
Na 157 mmol/L 144-160
K 3.3 mmol/L 3.5-5.8
Cl 112 mmol/L 109-122

Urine Test
30 Nov SG 1.025
PH 6
Sediment quiet
(Others all normal)

8Dec SG 1.026
PH 7
(Others all normal)
*Others – blood, bilirubin, urobilinogen, ketones, glucose, protein, nitrite & nitrite

Now, I was feeding my dog with 30mg Trilostane on 8:00am with wet food & liver support + hip & joint supplement at night. The vet requests me measure of her water intake in 24hrs & also suggests do 3rd ACTH Stim test to see whether need to add the dosage.

On the other hand, I’m worry about her liver & kidney function even has gone down a bit on 2nd blood test but still high.

Anyone could give me advisement? Are there any comments on this? As I don’t know what are they presentation of the test?

thanks a lot!

[labblab]

I have only a few moments right now to reply, so I'm afraid that I'm not able to carefully look at all the test results. But your baby's ACTH "post" result is still very high at 33 ug/dl. So even though it is lower than it was before you started the trilostane, it is still not close to the treatment range that is hoped for: no more than 9.1 ug/dl with symptoms well controlled. However, since your baby's original cortisol level was SO extremely high, this does still represent a significant change. As your vet says, though, you may very well need to consider a dosing increase if the next test does not show that the cortisol has decreased any further. Can you tell us what dose of trilostane your baby is taking?

Marianne

[BestBuddy]

Hi

I just had a quick look back and saw that your baby was 4.6kg (10 lbs)and was taking 30mg trilostane once a day...did I get that right?

For her size 30mg is at the higher end of the scale for her weight but the first ACTH showed a very high cortisol at post. You have seen a big reduction of the cortisol so it may be a good idea to leave that dosage for a few weeks and retest before making a decision to change.

Are you still seeing some good results?

Jenny

[Mavis]

yes, she's now taking 30mg once daily since day 1 with Cushing on 27Nov until to do 3rd ACTH Stim test on 20Dec.

The vet said they never seen such a high level before, so he suggests to to 3rd test to decide whether need to increase the dosage OR maintain 30mg on Trilostane. Meanwhile, they are happy to see the medication is works!

Upto this moment, she seems decrease water intake as around 300ml at 24hrs that is my count during Sat & Sun (but not know in weekday due to noboday at home)

But her hair loss is extremely serious almost nude except it still a less on her head :(

[BestBuddy]

Looking forward to the results of the next ACTH.

The hair takes a long time to improve and sometimes it gets worse before it gets better. How is her skin? My Buddy had very thin hair and even when we got the cortisol lower his skin was covered in scaly greasy flakes. I used Malaseb (a medicated shampoo) twice weekly to clear the skin and it was several months but the hair started to grow again, it was a different color but it looked great. The color changed back to normal after a couple of trims but it stayed healthy and looked pretty good.

I think it as about 4-5 months from when we started trilo to the improvement.

Jenny

[Mavis]

Will let you all know when she get 3rd ACTH test!

No, my dog didn't a problem like your Buddy of scaly greasy flakes but also thin coat & there are some acne + sarcoma on skin & 'black' spot. Now I'm scaring to trim for her as afraid she will lost her remain small amount of hair U_U:::

[Squirt's Mom]

Hi Mavis,

Some pups will do what we call "blowing" their coat after being on treatment for a bit. What that means is they will lose their old hair, sometimes really fast, but a new coat of hair comes back in after the old one is gone. It can be rather scary for moms and dads to see their baby who is feeling and acting better suddenly start to lose their hair, but it happens more than some would expect so don't panic if that happens to Dau Ting.

Looking forward to seeing the ACTH!

Hugs,
Leslie and the girls - always

[Mavis]

That's means I should keep comb her few hair out even peeling off? As her fur became thin, slender & weak before starting of treatment!! Her neck, belly, hind legs & tail has already all gone of fur...her hands & legs always frosty even I let her put on clothes!! & now a weather of Hong Kong just below 10 degree, she always shaking. I'm afraid she doesn't warm enough...

What should I do now? Any way could let her warm??

[mytil]

Hi Mavis,

There are little doggie sweaters that you can buy for her or even a little child's Tshirt or sweat shirt. This will let her body heat stay with her longer. I would watch though that the Tshirt or sweat shirt does not rub her skin too much as I am sure it is sensitive without the fur.

It may take a bit for you to see new hair growing since you have started treatment.

Keep us posted
Terry

[lulusmom]

Hi Mavis,

Can you tell us what breed Dau Ting is?

[Mavis]

She is Lhasa Apso but her outlook like Maltese, so I think she is properly mixed-up both of breed.

Due to HK is below 10 degree with rain now, finally I let her wear 2 clothes to keep warm ^^

[Mavis]

Hi All,

Anyone could give me some info as my dog’s 3rd ACTH stim test has outcome.

Now her 3rd post test was 30.1ug/dL & 831nmol/L. It seems not much control well & progress is slow down…my vet suggests increase dosage of 7.5mg (30mg x 25%) but nowhere provide the said dosage in Hong Kong!!

The vet is connecting with a manufacturer in Australia meanwhile the medicine is difficult to get approval by HK government. He now tries to convince with concern parties to let the medicine could be import to HK but undesirable condition.

During this period, my dog just can have keep to 30mg/daily.

He also offers me 2 options: 1) Double dosage to 60mg 2) Break the pill to be 4 portions (30mg/4 dosage) to feed my dog. For me, both options are not good!! I don’t know what can I do now??

At the same time, my dog did the 3rd blood test. ALKP & ALT are higher than 1st blood test. ALKP is 1023U/L (refer range 23-212) & ALT is 1000U/L (refer range 10-100), UREA is 19.7nmol/L (refer range 2.5-9.6).

There was no Jaundice in blood serum, due to the liver function reflected not good & we are not sure whether relative with Cushing, so my vet giving her some liver support supplement…

Happy New Year to all of you!!

[mytil]

It is perplexing that the third ACTH test does not show much of a decrease and is still very high and the symptoms are still present.

I am wondering if there is something else that is stopping some of the absorption of the Trilostane into her system. Other than liver support is there any other medication your girl is taking?

From the weight you mentioned above (4.6 kgs) the 30 mg dose seems to be acceptable and I am wondering too if it would be a good idea to split the 30 mg dosage and give twice daily - 15 mgs in the morning and 15 mgs in the evening (others will chime in on this too).

In my opinion I would be very hesitant to double the dosage to 60 mgs - could be far too much of a dose for her. If you do increase the current dose by 25% she would be taking 37.5 mgs (as you mentioned) - that dose range according to the product brochure is 2.2 to 6.7 mg/kg so that would be higher than the recommended dosage.

I know others with more direct experience with Trilostane will chime in.

Keep us posted
Terry

[lulusmom]

Hi Mavis,

I just reread your thread and want to say that, like your vet, I have never seen a dog with cortisol as high as Dau Ting's. Considering where the post cortisol was when you started treatment, the decrease at the 10 to 14 day mark was significant however, not much changed in the two weeks following. Were the last two acth stim tests done within 4 to 6 hours after dosing and was the dose given with a meal?

Cushing's will cause a mild to moderate increase in ALT but I consider Dau Ting's elevation to be severe. His ALT was 473 U/L prior to starting treatment with Trilostane, then dropped to 281 U/L two weeks after treatment. This makes sense because there was a significant drop in cortisol. What doesn't make sense is that the ALT has more than tripled in the last two weeks which makes me think that there is a lot more going on with Dau Ting than cushing's. If a non adrenal illness is causing this drastic elevation in ALT, it could have caused an increase in cortisol as well. Aside from the loss of hair, what symptoms does Dau Ting have now?

I was unaware that Trilostane came in tablet form as I have only seen capsules here in the states. If you have 30 mg tablets, the option to cut them in quarters, might not be a bad one if you need to add an additional 7.5mg to the daily dosing. I agree with Terry and would not feel comfortable with doubling the dose, especially if your vet cannot tell you for sure that there isn't something else going on with Dau Ting.

[Mavis]

In order to convenient for ACTH stim test, I was feeding her 30mg Trilostane with a bit of Royal Canine “Hepatic” canned food at 8:00am every morning. Then feed her Hip & Joint supplement after 30mins of trilostane.

After 2nd ACTH test, the vet gave her a liver support supplement named “Vetri-Same 90mg Denosyl” tablet once daily until 3rd ACTH test, who prescribed an additional liver support supplement named “Essentiale” 300mg capsule once daily together with Vetri-Same. Hence, she will take these 2 liver supplements together at night. However, she has had diarrhea with mucous membrane & “jelly” after took the additional supplement of Essentiale!

Now she would take Trilostane, hit & joint supplement in morning and 2 kind of liver support supplement at night.

As I know the vet drawn her 1st blood sample is performed in 4-5hrs (around 12:00-1:00pm) after medication at 8:00am. Then drawn 2nd blood sample in 1-2hrs after injection.

Obviously, her drinking intake & urination get positive improvement unless hair loss, thin skin & hind legs weakness. She keeps good appetite, good quality of sleeping & active, run around at home always!!

It maybe mislead all of you, Trilosatne is capsule! My meaning is the vet suggests split the capsule & pour out a powder to separate 4 portions to be 7.5mg (30mg x 25%) for feeding her. For me, it’s difficult!!

Something I’m suspecting: liver support supplement whether influence of the efficiency of Trilostane? As during 1st & 2nd ACTH test, she did not take liver supplement, ALT & ALKP was good result. BUT contrary to expection, it’s get worst for taking liver supplement.

After 3rd ACTH stim test & blood test, I’m confusing right now. I have no idea what’s going on with her? Is Cushing or other unknown disease??

[mytil]

I have just a minute, but wanted to let you know opening up the Trilostane capsule is not a good idea - your exposure to the powder as well as getting it equally distributed.

The regrowth of the hair that was lost may take some time. Generally they loose their fur and it takes time to grow back.

I will have to look up the liver support products to see the ingredients to determine if there is any conflict with the Trilostane.

More later
Terry

[spiritdog6]

It is very wrong your vet suggested to you to open capsules and divide. You are not a pharmacist! Do not do this! You may have to get compounded in lesser amounts, but NEVER divide a capsule yourself. Please.

[Mavis]

For safety, I’d rather my dog keep on 30mg once daily than divide the capsule! Although the healing is slowly but at least it has no risk for her, right?

My vet is back from Australia for a while who said order a difference of dosage is very easy at overseas but it’s very difficult in Hong Kong. Up to this moment, we stuck here…so depress!!

[AlisonandMia]

You may be able to get a pharmacist (chemist) to split the 30mg capsules you have into 15mg doses - or even 10mg doses. I'd imagine you would have pharmacists who can do this in Hong Kong.

Here in Australia, the UK and North America these pharmacists are called "compounding pharmacies". Quite a few members here have had larger doses they have bought recompounded into smaller doses this way.

It is certainly a job for a qualified pharmacist who has the right equipment to do it safely and accurately.

Alison

Here's a link to the Practicing Pharmacists Association of Hong Kong: http://www.ppahk.org/ Maybe if you contact them they could let you know of any compounding pharmacies you could use.

[Mavis]

Thanks, Alison ^^ I sent an email to the Practicing Pharmacists Association of Hong Kong for help & waiting for reply. Hope they can help on this!!

One the other hand, one of my friends who are in USA. Due to his vet does not seeing my dog, so he not allow to sell 7.5mg Tril to my friend…maybe try to let my vet fax the prescription to USA & my friend bring it back to me this month end? Does anyone know if the medicines export to HK without license?

[Squirt's Mom]

Hi Mavis,

I'm not sure, but maybe you could contact Dechra, the manufacturer of Trilostane, and find out from them if you can get the Trilo into Hong Kong.

Dechra Veterinary Products

7015 College Blvd.,
Suite 525,
Overland Park,
KS 66211


Tel: + 913-327-0015
Fax: + 913-327-0016

Hope this helps!
Hugs,
Leslie and the girls - always

[Tomato]

My dog, (Shi Tzu), Tomato is also 16 years old. He is newly diagnosed to have Cushing's disease. In fact, he just survived from a deadly condition of pancreatitis + hemorrhagic gastroenteritis that I almost lost him just before his birthday. His body weight dropped from 5.8kg to 4.4kg within about 2 weeks of hospitalization.

He started the 10mg Trilostane treatment (once daily) about a week ago, but the 2nd ACTH stimulation test showed that the post-stim level was still about 500 something. The vet said his condition is not very well controlled and the dosage has to be increased to 15mg. However, after Tomato started the Trilostane 10mg last week, I noticed that his appetite was decreased, and he started to pass soft stool.

I have two questions:

1) Should the dosage of Trilostane be increased to 15mg for Tomato’s condition especially given that he has signs of GI upset side-effects? However, the Vetoryl capsule only provides 10, 30 & 60mg dosage form. It won’t be a good idea to divide the capsule, right?

2) The cost of Vetoryl is quite expensive in Hong Kong. Does anyone know if there is any economical route to buy Vetoryl (in Hong Kong) or get it ship to Hong Kong? I searched some online pet pharmacies, however, it seems that they don’t accept overseas order nor prescriptions from non-UK registered Vet.

[Mavis]

Hi, long time hasn’t updated my dog’s status! Last week my dog did a further ACTH test & CBC blood test again that the data was 359nmol/L (last time was 831nmol/L on Dec10). Both are improved ^^

Now my vet suggests increase 10mg in totally 40mg once daily. However, my dog is getting thin (she dropped to 4.3kgs) which means 30mg is OD already. Am I right?! If she increases to be 40mg, can she handle it?

I am thinking about should she try to take 40mg OR keep current dosage as 30mg for safety? Actually her water intake & appetite were going to be normal and there are a bit of new hair is growing up now…

[Mavis]

Hi, Tomato’s parent. I’m sorry to answer you so late.

Are you also in Hong Kong? Is he fine now?

As for my experience, my Dau Ting has had a soft stool by early stage of taken Trilostane. After a few days, the situation is gone.

For increased to 15mg, did you tell to you vet know Tomato’s status for further follow-up?! Yes, you’re right! The capsule is not suggests to divide. My opinion, Tomato is keep on current dosage as 10mg is safety till find another better solution. However, even my dog dropped to 4.3kgs (5.8kgs last year), she is taking 30mg once daily & control is quite good.

I searched for purchasing a specific dosage from overseas (due to my dog need to increase 7.5mg now), it have to apply license from HK government & It seems very trouble & difficult!!

My vet who is a registered vet at Australia, so he could have prescription to Australia & ship to HK but the problem is we need to get license first! We also stuck here right now ><”

Hope it can help a bit on this!!

[Squirt's Mom]

Hi Mavis,

Good to hear from you!

How is Dau Ting acting? Are his signs still present? Are they as strong as they were or have they improved? The signs are as important as the numbers on the tests are - so if Dau Ting is no longer showing signs of Cushing's then I'm not sure I would increase the dose just now. However, if he is still displaying fairly strong signs, then an increase may be needed.

Wouldn't it be nice in Cushing's if one could ask a question and get a simple "yes" or "no" answer? :p It just seldom works that way - so many factors to consider.

Let us know how you think his signs are, ok?

Hugs,
Leslie and the gang

[apollo6]

Dear Mavis
Welcome
jumping from 10mg. to 40 mg. is to fast and high. It should only be a minor increase. Apollo is 12 years old weighs 10pounds( about 4.1kilo) I think and he is only on 10mg. When I did increase it was only to 12.5mg. He is back down to the 10mg. for know. Please check with your vet.
Hugs Sonja and Apollo

[lulusmom]

I believe Dau Ting has been on 30mg and Mavis probably meant to say that the vet wants to increase by 10mg, making the new dose 40mg. I'm sure Mavis will confirm that for us.

Glynda

[Mavis]

Per my observation, her signs have improved!

Her water intake around 150ml in 24hrs that is acceptable volume (4.3kgs), appetite is quite good, a bit of new hair is growing up slowly & urine is decreased but a little bit of more than normal I think (she will go to piss when wake up every time then going to drink). She is quite active, keep walking & running at home always ^^

Yes, lulusmon is correct. Since day 1 Dau Ting is taking 30mg once daily till now. Due to ACTH post-test was 359nmol/L (ideal would be within 150nmol/L), so the vet wants to increase by 10mg, making the new dose 40mg.

Due to her signs all seems back to quite normal. I’m thinking about shouldn’t she keep to 30mg more 2 months then does ACTH stim-test again to see any further improvement? As she is just taken medication for 4 months, it dropped from 3,395nmol/L at first to 359nmol/L now.

I’m afraid it’s too aggressive if jump to 40mg. Considering her aged 16yrs old I prefer her health is healing step-by-step mild!! Safe is first priority, right? What do you all think? I need all of your comments.

Many thanks!

[BestBuddy]

Hi,

I also like step by step healing.:D You are seeing some great results and maybe in another month those numbers will drop even more. If all problems are resolved and the post ACTH is under around 248 (9) then I would not push to get any better numbers.

Jenny

[lulusmom]

I agree with Jen. I think your plan to wait is a good one.

[Squirt's Mom]

Hi Mavis,

Thanks for the additional info. I, too, agree with the wait for now approach. You are doing a great job of watching her so you will know if her signs become stronger. Since they are getting better now on this dose, I wouldn't change it just yet.

With the running and playing, it sounds like she is feeling pretty good! :D That is GREAT!

Keep up the good work!
Hugs,
Leslie and the gang

[Mavis]

Thanks for all of your opinions, its really good share & support for me :D

ok, I will let my dog keep on current dose for more 2 months to see any improvement & keep an eye on her status, will let u all know!!

[Mavis]

Hey, everybody..just want to let you all know that my baby Dau Ting had passed away on 3May morning due to stroke (brain apoplexy) + Cushing estimated by vet....yup, it was a hard for me U_U:::

[BestBuddy]

Dear Mavis,

I am really sad to hear the Dau Ting lost the final battle. I know you will miss her but you will always have those good memories of the time you did have with her.

Another angel has their wings.

Jenny

[k9diabetes]

I am so sorry to learn that Dau Ting passed away. You were obviously very dedicated to her and to her medical care and I know you miss her terribly.

Natalie

[Squirt's Mom]

Dear Mavis,

I am so sorry to hear about Dau Ting. You worked so hard to help her have the best possible life and I know she was always grateful to you. The love you have for her shines through in your posts.

Dau Ting has been added to our Remembering List for 2011 where she will always be honored and remembered with love. When you feel like it, please feel free to write a memorial to her. You can do this at:

http://www.k9cushings.com/forum/forumdisplay.php?f=8

It would an honor to help you celebrate her life.

Please know we are here for you any time should you want to talk.

Our deepest sympathies,
Leslie, Squirt, Trinket, Brick and our Angels, Ruby and Crystal

[lulusmom]

Mavis, I am so terribly sorry for your loss. My thoughts and prayers are with you.

Godspeed Dau Ting.

Glynda

[Cindy Thoman]

Mavis, I am so sorry for your loss. My thoughts and prayers are with you.

xoxo,
Cindy and Alex

[jrepac]

Very sorry to hear this; I am sure you had a wonderful 16yrs with her...it's never enough, I know!

Jeff & Angel Mandy

[littleone1]

I am also so sorry for your loss, Mavis. My thoughts and prayers are with you.

Terri

[mytil]

I am so very sorry Mavis - my heart is with you.

[marie adams]

Dear Mavis,

As so many of us know, we feel your pain...

I am so sorry for your loss.:( Please remember all the good and wonderful times you spent together--it gets you through the rough times.

[Mavis]

Many thanks for your entire blessing & concern. I got it!!!

Yes, I have been having a rough time recently as lost my Dau Ting. Besides, my others 2 dogs had some problems at the meantime. One of my dog diagnosis with Kidney disease + middle level of Heart disease (he got 3~4 level at 6 level), another got a first-degree of Heart disease (he got 2 level at 6 level) also.

From now on, they’re taking Vetmedin 1.25mg for manage heart disease + Royal Canin Renal Diet for kidney. During this period, my dog need to do a frequently blood test for monitoring his kidney.

Hey all, I need your support to spend this tough time!! Hope be fine everything!!! God Bless…

[addy]

We are here for you Mavis. I am so sorry you have been going through so much with your beloved pups. We'll help you take it one day at a time.

Losing Dau Ting is hard enough but health issues with your other pups make it even harder for you.

Thinking of you and sending hugs.

Addy

[Squirt's Mom]

Hi Mavis,

Sometimes it seems like things just come at us all at once. :( I am sorry you are having to face illnesses in your other two babies just after losing sweet Dau Ting. You certainly have your hands, and heart, full right now.

Some of our members have, or are, dealing with kidney problems in their babies and I am sure they would be happy to answer any questions they could for you.

Don't forget to take some time just for yourself every now and then. Let yourself grieve when you need to - that is an important part of the healing process. We have soft shoulders and understanding hearts if you need to talk.

Hugs,
Leslie and the gang