Hi Pat and Peety: So sorry Peety is having such a bad time with the calcinosis. CoCo only has about 3 or 4 of the calcium deposits on his tail, or that is what the vet calls them. They actually look like warts. The vet prescribed the DMSO, but I have not used it since he only has a few spots. He has never even noticed them. There are lots of experienced people on this forum and the pups that have had the calcinosis did well on the Lysodren. That seems like a good idea to take Peety to the University of Gainsville. They will recommend something to help Peety. It is so awful to see your dog in pain. I am using the Vetoryl and it has lowered CoCo's cortisol, but he has lost a lot of his hair and it has not started growing back in, but maybe it will. I am sending healing thoughts your way and hope you find something to help Peety. Love, JoAnne