Hello, I have an 8 year old Alaskan Malamute named Yaco. He has been undergoing tests for about 2 years now, without a firm diagnose. And he is getting worse... . From the start we had a suspicion for cushing because of his symptoms. He had a surgery for his heel and his wounds wouldn’t heal, his hair didn’t grown back after shaving, he stopped shedding and his nice black & white coat became all brown/beige. His blood results showed a low T4 concentriation and although the tsh value was good, at that point our vet told us to start meds for hypothyroid. We did this for 1,5 year and everything kept getting worse even faster. He lost half his coat, he kept getting infection all over his body without a cause, we noticed him drinking and peeing a lot. And he was very tired again all the time. He fastly gains weight when we don’t put him on diet food, etc. ... . We had him castrated because one vet said it was Alopecia x. Didn’t help... . I suspected cushing and the specialist also dat the symptoms But they did a Ldds test and it was negative. So we had to keep looking they said. This was 1 year ago. So I went to do Some research myself and I noticed in his blood samples he also had high Alkalische fosfatasen, without the liver itself being bad. He had an echo done, But they told me due to his size and bad skin they could only see half of what was inside. So we did a CC ratio test which was positive (But the vet said this could have multiple causes). But everything kept pointing to cushing. The infection has now set on his bones already So we are getting scared for the future with no diagnose. So now we started with the vetoryl treatment because everything (except the Ldds test) points towards cushing. so his symptoms in a tot: muscle contractions, he had testikel atrofien(testicle atrophy), drinks lots, lots of peeing, he eats very good and gains lots of weight when we don’t pit him on a diet, hé has a low T4, his AF are Higher, his CC ratio test was high, he gets lots of infections on his skin and now also on his bond, hé doesn’t regrow any hair for 2 years, hé almost has no coat left, hé has black skin, ... I Will post blood results and acth and Ldds test results. who thougts on this and maybe recognizes something. I can’t post a picture from my cellphone, But Will down load from my computer. Thank you for your thoughts.